--- title: "Clovertex Target of the Month (05/25): BRAF" description: Here's the May 2025 Clovertex target of the month. image: https://cryoduck.com/hubfs/braf.png --- [Skip to content](https://cryoduck.com/blog/braf#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Jun 1, 2025 12:02:17 PM # Clovertex Target of the Month (05/25): BRAF ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/braf) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/braf) [envelope icon](mailto:?body=https://cryoduck.com/blog/braf) Clovertex’s May Target of the Month is B-Raf, a serine/threonine kinase that plays a central role in the MAPK signaling pathway, regulating cell growth and survival. Mutations in B-Raf, particularly the V600E variant, are well-known drivers of several aggressive cancers, including a subset of metastatic colorectal cancers (mCRC), which affect around 8–12% of mCRC patients and are associated with poor prognosis. This month’s spotlight follows a major development: Pfizer announced that its BRAFTOVI® (encorafenib) combination regimen, used alongside cetuximab and mFOLFOX6 chemotherapy, halved the risk of death in treatment-naïve patients with B-Raf V600E-mutant mCRC compared to standard chemotherapy. These results, presented at the 2025 ASCO Annual Meeting and published in the *New England Journal of Medicine*, represent a significant advancement in precision oncology and reinforce the critical role of targeted therapies in improving outcomes for patients with historically limited options. ![braf](https://cryoduck.com/hs-fs/hubfs/braf.png?width=1200&height=627&name=braf.png) The [Protein Imager](https://academic.oup.com/bioinformatics/article/36/9/2909/5701652?guestAccessKey=69bb093e-3b30-4468-ada7-3ea6ff198636&login=false) rendering displays the Cryo-EM Structure of the BRAF V600E monomer (PDB entry [8VYP](https://www.rcsb.org/structure/8VYP)).   ## About Clovertex Clovertex is an industry leader specializing in meeting the scientific IT needs of pharmaceutical companies, with a robust focus on cloud-based or on-premises cryo-EM processing. As an Advanced Tier Services Partner with Amazon Web Services (AWS), Clovertex leverages its comprehensive expertise to architect, build, automate, and manage software applications designed to meet specific research needs. Our all-encompassing solutions are meticulously tailored to streamline the complex processes associated with pharmaceutical research, underscoring our commitment to innovation, efficiency, and customer satisfaction. By integrating state-of-the-art technology with deep scientific understanding, Clovertex paves the way in optimizing the intersection of information technology and pharmaceutical development. ## Useful links 1. [Pfizer’s BRAFTOVI® Combination Regimen Cuts the Risk of Death in Half for Patients with BRAF V600E-Mutant Metastatic Colorectal Cancer](https://www.pfizer.com/news/press-release/press-release-detail/pfizers-braftovir-combination-regimen-cuts-risk-death-half) 2. Clovertex [website](http://clovertex.com) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## Related posts [![fxr](https://cryoduck.com/hs-fs/hubfs/GSPT1.png?height=200&name=GSPT1.png)](https://cryoduck.com/blog/gspt1) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (03/25): GSPT1](https://cryoduck.com/blog/gspt1) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Apr 6, 2025 4:27:31 PM Clovertex’s March Target of the Month is GSPT1, a translation termination factor that plays a vital... [Read more](https://cryoduck.com/blog/gspt1) [![hsa](https://cryoduck.com/hs-fs/hubfs/albumin.png?height=200&name=albumin.png)](https://cryoduck.com/blog/hsa) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (10/25): HSA](https://cryoduck.com/blog/hsa) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Nov 8, 2025 4:17:09 PM Clovertex’s October Target of the Month is human serum albumin, the body’s most abundant... [Read more](https://cryoduck.com/blog/hsa) [![fxr](https://cryoduck.com/hs-fs/hubfs/fxr.png?height=200&name=fxr.png)](https://cryoduck.com/blog/fxr) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (02/25): FXR](https://cryoduck.com/blog/fxr) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Mar 9, 2025 10:19:19 PM Clovertex's February Target of the Month is the farnesoid X receptor (FXR), a nuclear receptor that... 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