--- title: "Clovertex Target of the Month (11/23): FRalpha" description: August's 'Clovertex Drug Target of the Month' is the folate receptor alpha following the recent AbbVie acquisition of ImmunoGen. image: https://cryoduck.com/hubfs/FRalpha.png --- [Skip to content](https://cryoduck.com/blog/fralpha#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Dec 1, 2023 12:35:14 AM # Clovertex Target of the Month (11/23): FRalpha ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/fralpha) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/fralpha) [envelope icon](mailto:?body=https://cryoduck.com/blog/fralpha) This November, we highlight the folate receptor alpha (FRα) as the 'Clovertex Target of the Month'. This target plays a crucial role in advancing cancer treatments, particularly for ovarian cancer. FRα is the target of mirvetuximab soravtansine, an innovative antibody-drug conjugate (ADC) targeting cancers that overexpress FRα. This approach offers improved efficacy and reduced side effects compared to conventional chemotherapies. ![FRalpha](https://cryoduck.com/hs-fs/hubfs/FRalpha.png?width=1200&height=627&name=FRalpha.png) The spotlight on FRα has intensified with the recent news that AbbVie plans to acquire ImmunoGen for a staggering $10.1 billion centering around ImmunoGen's Elahere™ (mirvetuximab and soravtansine-gynx), a first-in-class ADC. Elahere has gained accelerated approval from the FDA as of November 2022, making history as the first targeted therapy to demonstrate a substantial survival benefit in patients with platinum-resistant ovarian cancer (PROC). This strategic move is set to boost AbbVie's oncology portfolio, specifically by speeding up its entry into the ovarian cancer market.  AbbVie's recent acquisition of ImmunoGen, highlighting the ADC Elahere, underscores the rising excitement and significance of antibody-drug conjugates in the pharmaceutical world. The featured model is the AF2 prediction of FRα (AlphaFold Database entry [P15328](https://alphafold.ebi.ac.uk/entry/P15328)).   ## About Clovertex Clovertex is an industry leader specializing in meeting the scientific IT needs of pharmaceutical companies, with a robust focus on cloud-based or on-premises cryo-EM processing. As an Advanced Tier Services Partner with Amazon Web Services (AWS), Clovertex leverages its comprehensive expertise to architect, build, automate, and manage software applications designed to meet specific research needs. Our all-encompassing solutions are meticulously tailored to streamline the complex processes associated with pharmaceutical research, underscoring our commitment to innovation, efficiency, and customer satisfaction. By integrating state-of-the-art technology with deep scientific understanding, Clovertex paves the way in optimizing the intersection of information technology and pharmaceutical development. ## Useful links 1. [AbbVie to Acquire ImmunoGen for $10.1B, Expanding Cancer Franchise](https://www.genengnews.com/topics/drug-discovery/abbvie-to-acquire-immunogen-for-10-1b-expanding-cancer-franchise/) 2. Clovertex [website](http://clovertex.com) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## Related posts [![her3](https://cryoduck.com/hs-fs/hubfs/HER3.png?height=200&name=HER3.png)](https://cryoduck.com/blog/her3) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## [Clovertex Target of the Month (10/23): HER3](https://cryoduck.com/blog/her3) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Oct 31, 2023 1:28:04 PM For October 2023, we have the Human Epidermal growth factor Receptor 3 (HER3) as the 'Clovertex... [Read more](https://cryoduck.com/blog/her3) [![AAV9](https://cryoduck.com/hs-fs/hubfs/Target%20of%20the%20month.png?height=200&name=Target%20of%20the%20month.png)](https://cryoduck.com/blog/gabaar) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## [Clovertex Target of the Month (08/23): GABAAR](https://cryoduck.com/blog/gabaar) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Aug 31, 2023 11:42:52 PM In August 2023, the GABAA receptor is highlighted our 'Clovertex Target of the Month' as the drug... [Read more](https://cryoduck.com/blog/gabaar) [![AAV9](https://cryoduck.com/hs-fs/hubfs/Target%20of%20the%20month-1.png?height=200&name=Target%20of%20the%20month-1.png)](https://cryoduck.com/blog/gpr61) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## [Clovertex Target of the Month (09/23): GPR61](https://cryoduck.com/blog/gpr61) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Sep 30, 2023 6:46:15 PM September's Clovertex Target of the Month is GPR61 following Pfizer's recent publication concerning... [Read more](https://cryoduck.com/blog/gpr61) # Stay connected: Follow and engage with us Contact form or email Get in touch with us by completing the [contact form](https://cryoduck.com/contact) on our website or simply send us an email. ![Email](https://cryoduck.com/hs-fs/hubfs/Email.png?width=980&height=67&name=Email.png)   Bi-monthly newsletter Subscribe to our [bi-monthly newsletter](https://cryoduck.com/newsletter) to receive a summary of recent developments and highlights. The cryoDuck Blog Follow [the cryoDuck Blog](https://cryoduck.com/the-cryoduck-blog) for commentary on everything related to cryo-EM in drug discovery. LinkedIn group: Cryo-EM in pharma and biotech Join our [LinkedIn group community](https://www.linkedin.com/groups/8888430/) to network with industry professionals and engage in discussions pertaining to cryo-EM in industry.  LinkedIn company page Follow our [LinkedIn company page](https://www.linkedin.com/company/94199435/)  for company updates and latest contents. [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png "cryoDuck Logo")](https://cryoduck.com) 5615EC 86, Netherlands --- [Contact](https://cryoduck.com/contact) [Privacy and Cookies Policy](https://cryoduck.com/privacy-and-cookies-policies) [Terms and Conditions](https://cryoduck.com/terms-and-conditions) --- Copyright © 2026, cryoDuck B.V. Cookie Settings ```json { "@context" : "https://schema.org", "@type" : "BlogPosting", "author" : { "@type" : "Person", "name" : "Mazdak Radjainia", "url" : "https://cryoduck.com/blog/author/mazdak-radjainia" }, "dateModified" : "2023-11-30T23:35:14.764Z", "datePublished" : "2023-11-30T23:35:14.000Z", "headline" : "Clovertex Target of the Month (11/23): FRalpha", "image" : [ "https://cryoduck.com/hubfs/FRalpha.png" ], "mainEntityOfPage" : { "@id" : "https://cryoduck.com/blog/fralpha", "@type" : "WebPage" }, "publisher" : { "@type" : "Organization", "logo" : { "@type" : "ImageObject", "url" : "https://cryoduck.com/hubfs/Home/horizontal%20light%20bg.png" }, "name" : "cryoDuck B.V." } } ```