--- title: "Clovertex Target of the Month (02/25): FXR" description: Here's the February 2025 Clovertex target of the month. image: https://cryoduck.com/hubfs/fxr.png --- [Skip to content](https://cryoduck.com/blog/fxr#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Mar 9, 2025 10:19:19 PM # Clovertex Target of the Month (02/25): FXR ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/fxr) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/fxr) [envelope icon](mailto:?body=https://cryoduck.com/blog/fxr) Clovertex's February Target of the Month is the farnesoid X receptor (FXR), a nuclear receptor that plays a pivotal role in regulating bile acid homeostasis, lipid metabolism, and glucose balance. FXRs, short for farnesoid X receptors, are mainly expressed in the liver and intestine, and FXR agonists are synthetic compounds thought to hold potential across several gastrointestinal (GI) diseases. FXR is in the spotlight following Eli Lilly and Company's acquisition of Organovo Holdings' FXR program, including the lead asset FXR314, for $10 million. FXR314 was previously in a Phase 2/3 trial for inflammatory bowel disease (IBD) and is considered Phase 2-ready for liver fibrosis, both areas where FXR modulation could offer new treatment options. By adding FXR314 to its pipeline, Eli Lilly is expanding its focus on diseases affecting the gut-liver axis, with the potential to improve care for patients with chronic digestive and metabolic disorders. ![fxr](https://cryoduck.com/hs-fs/hubfs/fxr.png?width=1200&height=627&name=fxr.png) The [Protein Imager](https://academic.oup.com/bioinformatics/article/36/9/2909/5701652?guestAccessKey=69bb093e-3b30-4468-ada7-3ea6ff198636&login=false) rendering displays the AlphaFold Database structure of bile acid receptor (PDB entry [Q96RI1](https://alphafold.ebi.ac.uk/entry/Q96RI1)).   ## About Clovertex Clovertex is an industry leader specializing in meeting the scientific IT needs of pharmaceutical companies, with a robust focus on cloud-based or on-premises cryo-EM processing. As an Advanced Tier Services Partner with Amazon Web Services (AWS), Clovertex leverages its comprehensive expertise to architect, build, automate, and manage software applications designed to meet specific research needs. Our all-encompassing solutions are meticulously tailored to streamline the complex processes associated with pharmaceutical research, underscoring our commitment to innovation, efficiency, and customer satisfaction. By integrating state-of-the-art technology with deep scientific understanding, Clovertex paves the way in optimizing the intersection of information technology and pharmaceutical development. ## Useful links 1. [Eli Lilly buys Organovo's FXR program for $10M](https://www.fiercebiotech.com/biotech/eli-lilly-buys-organovos-fxr-program-10m-sending-biotechs-skyrocketed-244) 2. Clovertex [website](http://clovertex.com) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## Related posts [![gipr](https://cryoduck.com/hs-fs/hubfs/gipr.png?height=200&name=gipr.png)](https://cryoduck.com/blog/gipr) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Year 2024: GIPR](https://cryoduck.com/blog/gipr) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Jan 13, 2025 11:10:08 AM Clovertex’s Target of the Year 2024 is the Gastric Inhibitory Polypeptide Receptor (GIPR), which... [Read more](https://cryoduck.com/blog/gipr) [![hsa](https://cryoduck.com/hs-fs/hubfs/albumin.png?height=200&name=albumin.png)](https://cryoduck.com/blog/hsa) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (10/25): HSA](https://cryoduck.com/blog/hsa) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Nov 8, 2025 4:17:09 PM Clovertex’s October Target of the Month is human serum albumin, the body’s most abundant... [Read more](https://cryoduck.com/blog/hsa) [![IDH1](https://cryoduck.com/hs-fs/hubfs/3dr2.png?height=200&name=3dr2.png)](https://cryoduck.com/blog/3dr2) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (10/24): XC5397](https://cryoduck.com/blog/3dr2) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Nov 4, 2024 12:48:41 AM Following this year’s Nobel Prize in Chemistry for breakthroughs in protein structure prediction... 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