--- title: "Clovertex Target of the Month (10/23): HER3" description: August's 'Clovertex Drug Target of the Month' is HER3 following the recent Merck-Daiichi Sankyo deal. image: https://cryoduck.com/hubfs/HER3.png --- [Skip to content](https://cryoduck.com/blog/her3#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Oct 31, 2023 1:28:04 PM # Clovertex Target of the Month (10/23): HER3 ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/her3) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/her3) [envelope icon](mailto:?body=https://cryoduck.com/blog/her3) For October 2023, we have the Human Epidermal growth factor Receptor 3 (HER3) as the 'Clovertex Drug Target of the Month'. In a busy month for the antibody-drug conjugate (ADC) field, the spotlight falls on HER3, a member of the EGFR family, pivotal in cancer progression pathways. ![HER3](https://cryoduck.com/hs-fs/hubfs/HER3.png?width=1200&height=627&name=HER3.png) HER3's prominence is underscored by Merck & Co. and Daiichi Sankyo’s collaboration, potentially worth up to $22 billion, to co-develop three ADC candidates targeting cancers. Patritumab deruxtecan (HER3-DXd), a frontrunner, is tailored for EGFR-mutated non-small cell lung cancer (NSCLC) post-progression on prior therapies. The FDA granted its Breakthrough Therapy Designation to patritumab deruxtecan in December 2021 and the companies plan to submit a biologics license application (BLA) for patritumab deruxtecan to the FDA by the end of March 2024. The protein model rendering features the cryo-EM structure of the HER2/HER3/NRG1b Heterodimer Extracellular Domain bound to Trastuzumab Fab (PDB [7MN8](https://www.rcsb.org/structure/7MN8)). ## About Clovertex Clovertex is an industry leader specializing in meeting the scientific IT needs of pharmaceutical companies, with a robust focus on cloud-based or on-premises cryo-EM processing. As an Advanced Tier Services Partner with Amazon Web Services (AWS), Clovertex leverages its comprehensive expertise to architect, build, automate, and manage software applications designed to meet specific research needs. Our all-encompassing solutions are meticulously tailored to streamline the complex processes associated with pharmaceutical research, underscoring our commitment to innovation, efficiency, and customer satisfaction. By integrating state-of-the-art technology with deep scientific understanding, Clovertex paves the way in optimizing the intersection of information technology and pharmaceutical development. ## Useful links 1. [Merck, Daiichi Sankyo Ink Up-to-$22B Cancer ADC Collaboration](https://www.genengnews.com/news/industry-news/merck-daiichi-sankyo-ink-up-to-22b-cancer-adc-collaboration/) 2. Clovertex [website](http://clovertex.com) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## Related posts [![her3](https://cryoduck.com/hs-fs/hubfs/FRalpha.png?height=200&name=FRalpha.png)](https://cryoduck.com/blog/fralpha) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## [Clovertex Target of the Month (11/23): FRalpha](https://cryoduck.com/blog/fralpha) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Dec 1, 2023 12:35:14 AM This November, we highlight the folate receptor alpha (FRα) as the 'Clovertex Target of the Month'.... [Read more](https://cryoduck.com/blog/fralpha) [![mc4r](https://cryoduck.com/hs-fs/hubfs/mc4r.png?height=200&name=mc4r.png)](https://cryoduck.com/blog/mc4r) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## [Clovertex Target of the Month (08/25): MC4R](https://cryoduck.com/blog/mc4r) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Sep 7, 2025 3:06:15 PM Clovertex’s August 2025 Target of the Month is MC4R (melanocortin‑4 receptor). MC4R is a GPCR that... [Read more](https://cryoduck.com/blog/mc4r) [![AAV9](https://cryoduck.com/hs-fs/hubfs/Target%20of%20the%20month-1.png?height=200&name=Target%20of%20the%20month-1.png)](https://cryoduck.com/blog/gpr61) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month), [membrane protein](https://cryoduck.com/blog/tag/membrane-protein) ## [Clovertex Target of the Month (09/23): GPR61](https://cryoduck.com/blog/gpr61) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Sep 30, 2023 6:46:15 PM September's Clovertex Target of the Month is GPR61 following Pfizer's recent publication concerning... 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