This month’s top posts, grouped by platform (Bluesky, X, and LinkedIn), showcase the latest cryo-EM...
cryoDuck Hottest Social in SBDD (03/2025)
This month, Cryo-EM provided new insights into the vitamin K enzyme, as well as channel and GPCR structures, highlighting the expanding range of targets. Structural studies of molecular glues also offered a clearer view of how these compounds influence protein interactions.
On the technology side, posts featured Direct Electron’s cameras and MicroED developments in drug discovery. The Cold Spring Harbor Cryo-EM course provided hands-on training in structure solving, with shared images capturing the process.
BlueSky cryo-EM & biotech
#CryoEM #structure of the human THIK-1 K2P K+ channel reveals a lower Y gate regulated by lipids and anesthetics. @NatureSMB Check this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9ft7
— UniTmp (@unitmporg.bsky.social) March 18, 2025 at 9:00 AM
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A Labeled Dataset for AI-based Cryo-EM Map Enhancement www.biorxiv.org/content/10.1101/2025.03.16.643562v1 #cryoEM
— cryoEM papers (@cryoempapers.bsky.social) March 18, 2025 at 8:12 AM
Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery. @biorxiv_preprint Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9eri
— UniTmp (@unitmporg.bsky.social) March 17, 2025 at 9:00 PM
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Happy St. Patrick's Day from the CSHL #cryoEM course! Data collection day for the final competition, but it looks like some mischievous leprechauns got into the microscope and messed up the autoloader… A tough but valuable lesson for the students: sometimes your resolution is limited by bad luck…
— Lander Lab (@landerlab.bsky.social) March 17, 2025 at 8:35 PM
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Very happy to share the work from my PhD is out today in @naturesmb.bsky.social ! Check it out here if you're interested in molecular glues, cryo-EM, deubiquitylating enzymes or immune signalling: www.nature.com/articles/s41...
— Francesca Chandler (@francescachandler.bsky.social) March 17, 2025 at 6:39 PM
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Happy to share our latest pre-print! We solved the cryoEM structures of human DNA repair factor MRN bound to DNA and to TRF2. Main work of Yilan, Filiz @filizkuybu.bsky.social and Hengjun. Great collab within the @sfb1361.bsky.social and @genecenter-lmu.bsky.social 🧬🔨 www.biorxiv.org/content/10.1...
— Hopfner Lab (@hopfnerlab.bsky.social) March 17, 2025 at 10:43 AM
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Ball-and-chain inactivation of a human large conductance calcium-activated potassium channel. @NatureComms Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9czh
— UniTmp (@unitmporg.bsky.social) March 17, 2025 at 9:00 AM
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A cryptic pocket in CB1 drives peripheral and functional selectivity. @Nature Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/9b65
— UniTmp (@unitmporg.bsky.social) March 16, 2025 at 9:00 PM
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Structural basis of CXCR4 assembly and regulation. @CellReports Check the #cryoEM #structure of this #membrane #protein in the UniTmp database: https://pdbtm.unitmp.org/entry/8yu7
— UniTmp (@unitmporg.bsky.social) March 16, 2025 at 9:00 AM
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Structure-guided design of partial agonists at an opioid receptor pubmed.ncbi.nlm.nih.gov/40082451/ #cryoEM
— cryoEM papers (@cryoempapers.bsky.social) March 16, 2025 at 4:52 AM
We've seen some good grids and some bad at the CSHL #CryoEM course, but I think we all agree that @miroastore.bsky.social should be awarded the 2025 "worst grid" award. But for someone who never held a pipette prior to this course he also deserves the "most improved" award - keep it up Miro!
— Lander Lab (@landerlab.bsky.social) March 16, 2025 at 4:48 AM
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Saturday night and the lab is in full swing as the participants of the CSHL #CryoEM course prepare for the final competition - solve the structure of a mystery protein in less than 4 hours.
— Lander Lab (@landerlab.bsky.social) March 16, 2025 at 1:52 AM
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Discover the secrets of vitamin K: New cryo-EM structures uncover the action of γ-glutamyl carboxylase, key for vital biological roles! 🔬 #VitaminKScience PMID:39880952, Nature 2025, @Nature https://doi.org/10.1038/s41586-024-08484-9 #Medsky #Pharmsky #RNA 🧪
— Shicheng Guo (@shihcheng.bsky.social) March 15, 2025 at 9:00 PM
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X/Twitter cryo-EM & biotech
Glad to share our new preprint, structure of the recently discovered Lamassu bacterial defense system, which is related to Rad50/Mre11 (RM). Our study reveals how Lamassu stays sequestered and activated after phage infection. pic.twitter.com/gMnnMUHr68
— Yan LI (@liyan19871127) March 16, 2025
Want to know what sets Direct Electron apart? Let our satisfied customers tell you!
— Direct Electron (@DirectElectron) March 10, 2025
To learn more about Apollo & our other ultra-fast cameras for Electron Microscopy & CryoEM, visit https://t.co/bPz50nD1dA pic.twitter.com/ZIiFBRKvtk
Happy to share our latest work. We characterize a type II Wadjet at Gruber lab and @DCI_EM with @drhonsworth , revealing unique traits—including a tandem KITE subunit, distinct coiled coil organization and a deviant hingehttps://t.co/MUNcmRYXgE pic.twitter.com/g1XC3y02Qs
— Florian Roisné-Hamelin (@RoisneHamelin_F) March 11, 2025
Vertebrate retrotransposons are the future of gene therapy. But how do they insert their genes? 🔥🔥
— Akanksha Thawani, PhD (@AkankshaThawani) November 13, 2024
Thrilled to present part 2 of my postdoctoral work with @NogalesLab @CollinsRNPLab @berkeleyMCB where we investigate this using #CryoEM and transgene insertion in 🧪 and cells! pic.twitter.com/pNxWCq8Zbp
Happy to share our manuscript on the in situ visualization of the copia retrotransposon in its final form today published in @CellCellPress https://t.co/bTSd8t4POV . What's new? pic.twitter.com/lRnHOB6oIZ
— Sven Klumpe (@svenklumpe) March 5, 2025
Did you know we were first to achieve Cryo-EM 3D reconstructions surpassing 3/4 Nyquist resolution with a direct detector? Learn more on our timeline cataloging the many big breakthroughs that make up our unique history.
— Direct Electron (@DirectElectron) March 5, 2025
Visit: https://t.co/xBolzuLTfx pic.twitter.com/gw6RRKjbYi
Here it is! We carefully check clips and rings one by one to remove damaged or bent. Still we recover 80% of them. In 2 years none failed in column. pic.twitter.com/mZsameHVbH
— Paolo Swuec (@PS_cryoEM) May 21, 2019
Now most folks cant tell the difference between an Xray diffraction pattern and #MicroED 😁
— Tamir Gonen 🎗️ (@gonenlab) March 6, 2025
Behold 0.9Å 😍 pic.twitter.com/6pWVwwHJbK
Our latest work shows how energy filtering, PFIB, and direct electron detection unlock sub-atomic resolution for #MicroED! 🎯
— Mike Martynowycz (@ScienceMick) March 6, 2025
Great work from @maxclabbers and JohanHattne back when I was with @gonenlab at @BC_UCLA. Excited to bring this capability to @UBuffalo! pic.twitter.com/gnZSN8I4Hc
Most protein research focuses on those known before the human genome was mapped.
— Prof. Nikolai Slavov (@slavov_n) March 8, 2025
1/2 pic.twitter.com/NnL8r69WVb
Before shot: New #cryoEM workstation.... pic.twitter.com/ryQDJSws1C
— Matthew Belousoff (@bluesocks81) March 7, 2025
Happy to share high throughput ligand and inhibitor screening against enzymes using MicroED. Drug discovery based on structures
— Tamir Gonen 🎗️ (@gonenlab) March 4, 2025
Ligand Screening and Discovery using Cocktail Soaking and Automated MicroED | bioRxiv https://t.co/4cWhylMBvg
Chinese biotech in 2025 🇨🇳. Lots of chatter, but still without a thorough look at what kinds of drugs China is actively developing.
— Dennis Gong (@GongDennis) February 26, 2025
To address this, I reviewed 54 Chinese biopharma pipelines, highlighting notable deals, assets, and trends pic.twitter.com/Ew0xAvFCY1
scFv16: The Unsung Heroes Behind a Critical Tool for GPCR Researchhttps://t.co/Dk5bCGTfGp
— Cheers (@raintank2010) February 23, 2025
Roche's decision to keep scFv16 open-access was not an oversight, but a deliberate commitment to advancing science.
LinkedIN cryo-EM & biotech
