April delivered no shortage of turbulence — but also a few genuine bright spots. Amid ongoing...
cryoDuck Hottest Social in SBDD (05/2025)
Bitter days for the industry, sweet days for cryo-EM. This month’s SBDD social pulse captures a striking contrast: as biotech reels from policy headwinds and investor pullback, cryo-EM continues to deliver structural biology breakthroughs like the structure of the human sweet taste receptor. Catch the top SBDD social buzz from May below.
BlueSky cryo-EM & biotech
Selection of nanobodies against liponanoparticle-embedded membrane proteins by yeast surface display www.biorxiv.org/content/10.1101/2025.05.20.655075v1 #cryoEM
— cryoEM papers (@cryoempapers.bsky.social) May 24, 2025 at 11:16 AM
De Novo Hydration of Cryo-EM Reconstructions through Molecular Dynamics Simulations of the Excess Chemical Potential www.biorxiv.org/content/10.1101/2025.05.23.655847v1 #cryoEM
— cryoEM papers (@cryoempapers.bsky.social) May 24, 2025 at 9:10 AM
Time-resolved cryo-EM movies have mapped 16 distinct shapes formed by dynein and Lis1 proteins, offering new structural insight that could inform therapies for neurological disorders. doi.org/g9k5sw
— Science X / Phys.org (@sciencex.bsky.social) May 23, 2025 at 7:47 PM
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If your test for ground-breaking discoveries can't detect the discovery of RNAi, or of CRISPR-Cas9, or the cryoEM resolution revolution or Alphafold2, maybe it's not a very good test. www.nature.com/articles/d41...
— Stephen Curry (@scurry.bsky.social) May 23, 2025 at 7:32 PM
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"State of the art and developments in Cryo-EM sample preparation methods for macromolecular machines" described in our book chapter #cryo-em #structuralbiology #membraneproteins #proteinstructure
— BvK LaB (@bvklab.bsky.social) May 23, 2025 at 2:20 PM
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An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation 👉 buff.ly/hDgWZMA #cryoEM #StructuralBiology #CryoET
— febsopenbio.bsky.social (@febsopenbio.bsky.social) May 23, 2025 at 11:55 AM
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X/Twitter cryo-EM & biotech
Stages of Biotech Investing…
— Gene Investing w/Anthony 🧬 (@GeneInvesting) May 14, 2025
1. Buying the best/coolest companies because there should be value even if profits are years out.
2. Buying more of it because it's not years out anymore and derisked with best in class data.
3. Oh, that doesn't work in this current market? Okay… pic.twitter.com/1OwRN7yHN6
Biotech is totally broken. It's not investable even the specialist are getting smoked… again! If you are a generalist or institutional money why on earth would you want to own biotech?
— BioHunter (@TheBio_Hunter) May 14, 2025
Lots of blame to go around, but these biotech BOD's share a lot of the blame… yes…
Hi Cryo-EM fellas!
— Misha Kudryashev 🔬 ❄🕊️ (@MishaKudryashev) April 28, 2025
What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma? pic.twitter.com/TqH441IgLN
Wow, wow, wow!!!
— BryanRoth (@zenbrainest) May 7, 2025
The structure of human sweetness https://t.co/Cok9PiQJ3M
Making cryo-EM grids by flying particles through a native mass-spec is pretty cool, but can it be cooler? Yes - by adding a LASER! Particles damaged by the process can be fixed by adding a thin layer of ice then briefly hitting the grid with a laser!https://t.co/vLigmoE69X
— Tim Grant (@GrantCryoEMLab) May 9, 2025
This week's genome editing triumph is a big deal.
— Eric Topol (@EricTopol) May 18, 2025
Here's whyhttps://t.co/1ajD3p3ksi pic.twitter.com/lXpHEcNsbW
How long before $PFE buys a Chinese obesity drug?
— Adam Feuerstein ✡️ (@adamfeuerstein) May 20, 2025
New organelle uncovered by in situ #cryoET: the #hemifusome, a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do.https://t.co/ZlP3wzqYbc#CryoET #MembraneBiogenesis #Organelle
— Bechara Kachar (@BecharaKachar) May 19, 2025
🧵1/5 pic.twitter.com/UNhBFnC2La
Received this lovely little "Bloodbath" chart from a friend this morning. I guess the moral of the story is if you lost money in the first quarter in biotech, you have plenty of good company. pic.twitter.com/bgyN0PuRBe
— Osprey Capital (@MBbiotech) May 21, 2025
I had a double-take here. McDonalds' global chief comms officer is leaving for...weight loss drugmaker Eli Lilly. https://t.co/scnxnkXt2V
— Max Bayer (@maxonwifi) May 20, 2025
🇨🇳🇺🇸Discovered in China, Scaled in America: The $6B Cancer Deal That Could Reshape China–US Biotech$PFE just paid $1.25B upfront to license a PD-1 x VEGF bispecific from China's 3SBio.
— BowTiedBiotech 🧪🔬🧬 (@BowTiedBiotech) May 22, 2025
It's one of the richest Chinese biotech deals ever.
But this isn't about one molecule. It's… pic.twitter.com/cHeepQ1r41
First-ever EBSD orientation maps of hafnia & hafnon: using SEMCam + dictionary indexing, researchers overcame beam sensitivity & low symmetry challenges in ceramics. A new path for difficult materials. Read more: https://t.co/OByWipW6dU pic.twitter.com/TAy9zNDUxV
— Direct Electron (@DirectElectron) May 23, 2025
Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors
— Fitzpatrick Laboratory (@FitzpatrickLab) May 7, 2025
Now, an exciting collaboration between our labs @ColumbiaBiochem reveals the #cryoEM structure of the human sweet receptor-key to sweet taste perception-online @CellCellPress!https://t.co/o6AQqpmuJo pic.twitter.com/QGTLhXx7Ru
We've recently expanded our manufacturing facilities to scale production while upholding the high quality, exacting precision & unparalleled speed our direct detection cameras are known for—meeting growing demand without compromise!
— Direct Electron (@DirectElectron) May 20, 2025
Learn more at https://t.co/Yy9yRY6ghT pic.twitter.com/j0q2pNOvsp
Structural dynamics and permeability of the TRPV3 pentamer | Nature Communications https://t.co/6UdTfruYUm
— Uijin_Kim (@uijin311) May 19, 2025
Useful!https://t.co/HcbslBwYZk
— BryanRoth (@zenbrainest) May 16, 2025
So many boxes 😍 pic.twitter.com/YYoQ8W7vvG
— Tamir Gonen (@gonenlab) May 13, 2025
You want to start tomography? Solve structures inside cells? Reach Nyquist😳?
— Florent Waltz (@FlorentWaltz) May 7, 2025
We have a website for you! https://t.co/ulvbbhEY6d
You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software!
Hope it will be useful ! pic.twitter.com/TAfZ9MeVzI
Check out our review article on the structural and functional studies of retrotransposon proteins by @AkankshaThawani together with @CollinsRNPLab.https://t.co/N72Njjofhx
— The Nogales Lab (@NogalesLab) May 8, 2025
LinkedIN cryo-EM & biotech