---
title: cryoDuck Hottest Social in SBDD (05/2025)
description: Each month, we sift through the fragmented world of X, BlueSky, LinkedIn, and beyond to spotlight the most compelling discussions in structural biology and drug discovery.
image: https://cryoduck.com/hubfs/Hottest%20Social%20SBDD.png
---

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 May 25, 2025 2:02:44 AM

# cryoDuck Hottest Social in SBDD (05/2025)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia)

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Bitter days for the industry, sweet days for cryo-EM. This month’s SBDD social pulse captures a striking contrast: as biotech reels from policy headwinds and investor pullback, cryo-EM continues to deliver structural biology breakthroughs like the structure of the human sweet taste receptor. Catch the top SBDD social buzz from May below.

![Hottest Social SBDD](https://cryoduck.com/hs-fs/hubfs/Hottest%20Social%20SBDD.png?width=1200&height=627&name=Hottest%20Social%20SBDD.png)

 

BlueSky cryo-EM & biotech

> Selection of nanobodies against liponanoparticle-embedded membrane proteins by yeast surface display www.biorxiv.org/content/10.1101/2025.05.20.655075v1 #cryoEM
> 
> — cryoEM papers ([@cryoempapers.bsky.social](https://bsky.app/profile/did:plc:iidfr4ee72rynh4277xftz4d?ref_src=embed)) [May 24, 2025 at 11:16 AM](https://bsky.app/profile/did:plc:iidfr4ee72rynh4277xftz4d/post/3lpvspbtqhr2j?ref_src=embed)

> De Novo Hydration of Cryo-EM Reconstructions through Molecular Dynamics Simulations of the Excess Chemical Potential www.biorxiv.org/content/10.1101/2025.05.23.655847v1 #cryoEM
> 
> — cryoEM papers ([@cryoempapers.bsky.social](https://bsky.app/profile/did:plc:iidfr4ee72rynh4277xftz4d?ref_src=embed)) [May 24, 2025 at 9:10 AM](https://bsky.app/profile/did:plc:iidfr4ee72rynh4277xftz4d/post/3lpvlowvrn52x?ref_src=embed)

> Time-resolved cryo-EM movies have mapped 16 distinct shapes formed by dynein and Lis1 proteins, offering new structural insight that could inform therapies for neurological disorders. doi.org/g9k5sw
> 
> [\[image or embed\]](https://bsky.app/profile/did:plc:ipnqgjcngbafxdo3bv3gamrx/post/3lpu6si43k525?ref_src=embed)
> 
> — Science X / Phys.org ([@sciencex.bsky.social](https://bsky.app/profile/did:plc:ipnqgjcngbafxdo3bv3gamrx?ref_src=embed)) [May 23, 2025 at 7:47 PM](https://bsky.app/profile/did:plc:ipnqgjcngbafxdo3bv3gamrx/post/3lpu6si43k525?ref_src=embed)

> If your test for ground-breaking discoveries can't detect the discovery of RNAi, or of CRISPR-Cas9, or the cryoEM resolution revolution or Alphafold2, maybe it's not a very good test. www.nature.com/articles/d41...
> 
> [\[image or embed\]](https://bsky.app/profile/did:plc:jviud2kbpxo3lwd3do4mqepg/post/3lpu5xotlbk2j?ref_src=embed)
> 
> — Stephen Curry ([@scurry.bsky.social](https://bsky.app/profile/did:plc:jviud2kbpxo3lwd3do4mqepg?ref_src=embed)) [May 23, 2025 at 7:32 PM](https://bsky.app/profile/did:plc:jviud2kbpxo3lwd3do4mqepg/post/3lpu5xotlbk2j?ref_src=embed)

> "State of the art and developments in Cryo-EM sample preparation methods for macromolecular machines" described in our book chapter #cryo-em #structuralbiology #membraneproteins #proteinstructure
> 
> [\[image or embed\]](https://bsky.app/profile/did:plc:4xwdgprodwuluecooatjbg7f/post/3lptmlutnx22j?ref_src=embed)
> 
> — BvK LaB ([@bvklab.bsky.social](https://bsky.app/profile/did:plc:4xwdgprodwuluecooatjbg7f?ref_src=embed)) [May 23, 2025 at 2:20 PM](https://bsky.app/profile/did:plc:4xwdgprodwuluecooatjbg7f/post/3lptmlutnx22j?ref_src=embed)

> An approach for coherent periodogram averaging of tilt-series data for improved contrast transfer function estimation 👉 buff.ly/hDgWZMA #cryoEM #StructuralBiology #CryoET
> 
> [\[image or embed\]](https://bsky.app/profile/did:plc:4tcumaj3dawyy5c6kofpgvdz/post/3lpteg5qq4l2k?ref_src=embed)
> 
> — febsopenbio.bsky.social ([@febsopenbio.bsky.social](https://bsky.app/profile/did:plc:4tcumaj3dawyy5c6kofpgvdz?ref_src=embed)) [May 23, 2025 at 11:55 AM](https://bsky.app/profile/did:plc:4tcumaj3dawyy5c6kofpgvdz/post/3lpteg5qq4l2k?ref_src=embed)

 

X/Twitter cryo-EM & biotech

> Stages of Biotech Investing…
> 
> 1. Buying the best/coolest companies because there should be value even if profits are years out.
> 
> 2. Buying more of it because it's not years out anymore and derisked with best in class data.
> 
> 3. Oh, that doesn't work in this current market? Okay… [pic.twitter.com/1OwRN7yHN6](https://t.co/1OwRN7yHN6)
> 
> — Gene Investing w/Anthony 🧬 (@GeneInvesting) [May 14, 2025](https://twitter.com/GeneInvesting/status/1922681479882301677?ref_src=twsrc%5Etfw)

> Biotech is totally broken. It's not investable even the specialist are getting smoked… again! If you are a generalist or institutional money why on earth would you want to own biotech?
> 
> Lots of blame to go around, but these biotech BOD's share a lot of the blame… yes…
> 
> — BioHunter (@TheBio\_Hunter) [May 14, 2025](https://twitter.com/TheBio_Hunter/status/1922709840410853879?ref_src=twsrc%5Etfw)

> Hi Cryo-EM fellas!
> 
> What are the pros and cons of the latest cryoFIB milling tools? Any usage experience with Arctis already? Any huge advantages of plasma? [pic.twitter.com/TqH441IgLN](https://t.co/TqH441IgLN)
> 
> — Misha Kudryashev 🔬 ❄🕊️ (@MishaKudryashev) [April 28, 2025](https://twitter.com/MishaKudryashev/status/1916718989515907254?ref_src=twsrc%5Etfw)

> Wow, wow, wow!!!  
> The structure of human sweetness [https://t.co/Cok9PiQJ3M](https://t.co/Cok9PiQJ3M)
> 
> — BryanRoth (@zenbrainest) [May 7, 2025](https://twitter.com/zenbrainest/status/1920142154372190498?ref_src=twsrc%5Etfw)

> Making cryo-EM grids by flying particles through a native mass-spec is pretty cool, but can it be cooler? Yes - by adding a LASER! Particles damaged by the process can be fixed by adding a thin layer of ice then briefly hitting the grid with a laser![https://t.co/vLigmoE69X](https://t.co/vLigmoE69X)
> 
> — Tim Grant (@GrantCryoEMLab) [May 9, 2025](https://twitter.com/GrantCryoEMLab/status/1920892445631373749?ref_src=twsrc%5Etfw)

> This week's genome editing triumph is a big deal.  
> Here's why[https://t.co/1ajD3p3ksi](https://t.co/1ajD3p3ksi) [pic.twitter.com/lXpHEcNsbW](https://t.co/lXpHEcNsbW)
> 
> — Eric Topol (@EricTopol) [May 18, 2025](https://twitter.com/EricTopol/status/1924113238977064965?ref_src=twsrc%5Etfw)

> How long before [$PFE](https://twitter.com/search?q=%24PFE&src=ctag&ref_src=twsrc%5Etfw) buys a Chinese obesity drug?
> 
> — Adam Feuerstein ✡️ (@adamfeuerstein) [May 20, 2025](https://twitter.com/adamfeuerstein/status/1924623151289258449?ref_src=twsrc%5Etfw)

> New organelle uncovered by in situ [#cryoET](https://twitter.com/hashtag/cryoET?src=hash&ref_src=twsrc%5Etfw): the [#hemifusome](https://twitter.com/hashtag/hemifusome?src=hash&ref_src=twsrc%5Etfw), a stable, hemifused vesicle pair separated by an extended hemifusion diaphragm. This structure redefines what membrane fusion intermediates can do.[https://t.co/ZlP3wzqYbc](https://t.co/ZlP3wzqYbc)[#CryoET](https://twitter.com/hashtag/CryoET?src=hash&ref_src=twsrc%5Etfw) [#MembraneBiogenesis](https://twitter.com/hashtag/MembraneBiogenesis?src=hash&ref_src=twsrc%5Etfw) [#Organelle](https://twitter.com/hashtag/Organelle?src=hash&ref_src=twsrc%5Etfw)
> 
> 🧵1/5 [pic.twitter.com/UNhBFnC2La](https://t.co/UNhBFnC2La)
> 
> — Bechara Kachar (@BecharaKachar) [May 19, 2025](https://twitter.com/BecharaKachar/status/1924286008100544708?ref_src=twsrc%5Etfw)

> Received this lovely little "Bloodbath" chart from a friend this morning. I guess the moral of the story is if you lost money in the first quarter in biotech, you have plenty of good company. [pic.twitter.com/bgyN0PuRBe](https://t.co/bgyN0PuRBe)
> 
> — Osprey Capital (@MBbiotech) [May 21, 2025](https://twitter.com/MBbiotech/status/1925123717287346356?ref_src=twsrc%5Etfw)

> I had a double-take here. McDonalds' global chief comms officer is leaving for...weight loss drugmaker Eli Lilly. [https://t.co/scnxnkXt2V](https://t.co/scnxnkXt2V)
> 
> — Max Bayer (@maxonwifi) [May 20, 2025](https://twitter.com/maxonwifi/status/1924867944573505999?ref_src=twsrc%5Etfw)

> 🇨🇳🇺🇸Discovered in China, Scaled in America: The $6B Cancer Deal That Could Reshape China–US Biotech[$PFE](https://twitter.com/search?q=%24PFE&src=ctag&ref_src=twsrc%5Etfw) just paid $1.25B upfront to license a PD-1 x VEGF bispecific from China's 3SBio.
> 
> It's one of the richest Chinese biotech deals ever.
> 
> But this isn't about one molecule. It's… [pic.twitter.com/cHeepQ1r41](https://t.co/cHeepQ1r41)
> 
> — BowTiedBiotech 🧪🔬🧬 (@BowTiedBiotech) [May 22, 2025](https://twitter.com/BowTiedBiotech/status/1925517742641221699?ref_src=twsrc%5Etfw)

> First-ever EBSD orientation maps of hafnia & hafnon: using SEMCam + dictionary indexing, researchers overcame beam sensitivity & low symmetry challenges in ceramics. A new path for difficult materials. Read more: [https://t.co/OByWipW6dU](https://t.co/OByWipW6dU) [pic.twitter.com/TAy9zNDUxV](https://t.co/TAy9zNDUxV)
> 
> — Direct Electron (@DirectElectron) [May 23, 2025](https://twitter.com/DirectElectron/status/1926005533124829512?ref_src=twsrc%5Etfw)

> Over 20 years ago, Zuker et al. discovered the mammalian sweet taste receptors
> 
> Now, an exciting collaboration between our labs [@ColumbiaBiochem](https://twitter.com/ColumbiaBiochem?ref_src=twsrc%5Etfw) reveals the [#cryoEM](https://twitter.com/hashtag/cryoEM?src=hash&ref_src=twsrc%5Etfw) structure of the human sweet receptor-key to sweet taste perception-online [@CellCellPress](https://twitter.com/CellCellPress?ref_src=twsrc%5Etfw)![https://t.co/o6AQqpmuJo](https://t.co/o6AQqpmuJo) [pic.twitter.com/QGTLhXx7Ru](https://t.co/QGTLhXx7Ru)
> 
> — Fitzpatrick Laboratory (@FitzpatrickLab) [May 7, 2025](https://twitter.com/FitzpatrickLab/status/1920138941430206846?ref_src=twsrc%5Etfw)

> We've recently expanded our manufacturing facilities to scale production while upholding the high quality, exacting precision & unparalleled speed our direct detection cameras are known for—meeting growing demand without compromise!
> 
> Learn more at [https://t.co/Yy9yRY6ghT](https://t.co/Yy9yRY6ghT) [pic.twitter.com/j0q2pNOvsp](https://t.co/j0q2pNOvsp)
> 
> — Direct Electron (@DirectElectron) [May 20, 2025](https://twitter.com/DirectElectron/status/1924963491615588564?ref_src=twsrc%5Etfw)

> Structural dynamics and permeability of the TRPV3 pentamer | Nature Communications [https://t.co/6UdTfruYUm](https://t.co/6UdTfruYUm)
> 
> — Uijin\_Kim (@uijin311) [May 19, 2025](https://twitter.com/uijin311/status/1924255589817086090?ref_src=twsrc%5Etfw)

> Useful![https://t.co/HcbslBwYZk](https://t.co/HcbslBwYZk)
> 
> — BryanRoth (@zenbrainest) [May 16, 2025](https://twitter.com/zenbrainest/status/1923419451594059957?ref_src=twsrc%5Etfw)

> So many boxes 😍 [pic.twitter.com/YYoQ8W7vvG](https://t.co/YYoQ8W7vvG)
> 
> — Tamir Gonen (@gonenlab) [May 13, 2025](https://twitter.com/gonenlab/status/1922317090200928657?ref_src=twsrc%5Etfw)

> You want to start tomography? Solve structures inside cells? Reach Nyquist😳?  
> We have a website for you! [https://t.co/ulvbbhEY6d](https://t.co/ulvbbhEY6d)   
> You'll find a tutorial on how to reconstruct tomograms, pick particles and do subtomo averaging, using different software!   
> Hope it will be useful ! [pic.twitter.com/TAfZ9MeVzI](https://t.co/TAfZ9MeVzI)
> 
> — Florent Waltz (@FlorentWaltz) [May 7, 2025](https://twitter.com/FlorentWaltz/status/1920042425977876612?ref_src=twsrc%5Etfw)

> Check out our review article on the structural and functional studies of retrotransposon proteins by [@AkankshaThawani](https://twitter.com/AkankshaThawani?ref_src=twsrc%5Etfw) together with [@CollinsRNPLab](https://twitter.com/CollinsRNPLab?ref_src=twsrc%5Etfw).[https://t.co/N72Njjofhx](https://t.co/N72Njjofhx)
> 
> — The Nogales Lab (@NogalesLab) [May 8, 2025](https://twitter.com/NogalesLab/status/1920579305463017591?ref_src=twsrc%5Etfw)

 

LinkedIN cryo-EM & biotech

 

[hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## Related posts

[![Hottest Social](https://cryoduck.com/hs-fs/hubfs/Hottest%20Social%20SBDD.png?height=200&name=Hottest%20Social%20SBDD.png)](https://cryoduck.com/blog/hottest-social-0225)

[hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [cryoDuck Hottest Social in SBDD (02/2025)](https://cryoduck.com/blog/hottest-social-0225)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Feb 15, 2025 6:06:41 PM

This month’s top posts, grouped by platform (Bluesky, X, and LinkedIn), showcase the latest cryo-EM...

[Read more](https://cryoduck.com/blog/hottest-social-0225)

[![Hottest Social](https://cryoduck.com/hs-fs/hubfs/Hottest%20Social%20SBDD.png?height=200&name=Hottest%20Social%20SBDD.png)](https://cryoduck.com/blog/hottest-social-0425)

[hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [cryoDuck Hottest Social in SBDD (04/2025)](https://cryoduck.com/blog/hottest-social-0425)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Apr 27, 2025 11:31:34 AM

April delivered no shortage of turbulence — but also a few genuine bright spots. Amid ongoing...

[Read more](https://cryoduck.com/blog/hottest-social-0425)

[![Hottest Social](https://cryoduck.com/hs-fs/hubfs/Hottest%20Social%20SBDD.png?height=200&name=Hottest%20Social%20SBDD.png)](https://cryoduck.com/blog/hottest-social-0325)

[hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [cryoDuck Hottest Social in SBDD (03/2025)](https://cryoduck.com/blog/hottest-social-0325)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Mar 18, 2025 12:55:31 PM

This month, Cryo-EM provided new insights into the vitamin K enzyme, as well as channel and GPCR...

[Read more](https://cryoduck.com/blog/hottest-social-0325)

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