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cryoDuck Hottest Social in SBDD (04/2025)

Picture of Mazdak Radjainia

April delivered no shortage of turbulence — but also a few genuine bright spots.
Amid ongoing instability across biotech and science funding, OpenAI’s rumored plans to launch an X/Twitter alternative offered a rare flash of optimism for online scientific communities. Cryo-EM, quite literally, got even cooler with the rebirth of helium-cooled microscopes. CryoSPARC 4.7 arrived with meaningful workflow improvements, while Thermo Fisher leaned into corporate cinema flair, promoting the new Krios 5 against sweeping jungle backdrops and scenes of children playing in the dusts of Africa. And in a moment that neatly captured the broader mood: the 3DEM mailing list collapsed into an infinite loop of out-of-office auto-replies.

Hottest Social SBDD

 

BlueSky cryo-EM & biotech

A large, general and modular DARPin-apoferritin scaffold enables the visualization of small proteins by cryo-EM pubmed.ncbi.nlm.nih.gov/40277178/ #cryoEM

— cryoEM papers (@cryoempapers.bsky.social) April 26, 2025 at 2:55 PM

New SLC33A1 cryo-EM structure in Cell Discovery, unlocked by Salipro®! The study reveals key drug discovery insights for neurodegeneration & cancer. Great work by the authors! Full study: www.nature.com/articles/s41... #Salipro #CryoEM #SLC33A1 #DrugDiscovery #MembraneProtein #StructuralBiology

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— Salipro Biotech (@saliprobiotech.bsky.social) April 25, 2025 at 11:40 AM

🦠🧠 MemBrain update! 🧠🦠 We've updated our preprint! It now covers the full MemBrain v2 pipeline for end-to-end membrane analysis in #CryoET: segmentation, particle picking, and spatial statistics. 🔗 Preprint: doi.org/10.1101/2024... 🔗 Code: github.com/CellArchLab/... 🧵(1/6) #TeamTomo

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— Lorenz Lamm (@lorenzlamm.bsky.social) April 25, 2025 at 9:28 AM

📜 Transport of phenoxyacetic acid herbicides by PIN-FORMED auxin transporters 🧑‍🔬 @lukas-schulz.bsky.social, @unglam.bsky.social, @bjornppedersen.bsky.social, @uhammes.bsky.social, et al. 📔 @natplants.nature.com 🔗 www.nature.com/articles/s41... #️⃣ #PlantScience #Phytohormones #Auxin #CryoEM

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— Marc Somssich (@somssich.bsky.social) April 25, 2025 at 9:23 AM

Nickel-NTA lipid-monolayer affinity grids allow for high-resolution structure determination by cryo-EM www.biorxiv.org/content/10.1101/2025.04.24.650495v1 #cryoEM

— cryoEM papers (@cryoempapers.bsky.social) April 25, 2025 at 9:10 AM

Enjoyed this newly-published guide to Cryo-EM for battery research! Some great points to think about when aiming to make battery EM as quantitative as possible.

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— electro-them-istry 🏳️‍🌈 (@electro-them-istry.bsky.social) April 24, 2025 at 10:52 PM

Simultaneous polyclonal antibody sequencing and epitope mapping by cryo electron microscopy and mass spectrometry pubmed.ncbi.nlm.nih.gov/40266252/ #cryoEM

— cryoEM papers (@cryoempapers.bsky.social) April 24, 2025 at 10:35 PM

We have determined the first #cryoEM structures of human GlyT2 bound to a potent pseudo-irreversible inhibitor (ORG25543) that failed in pre-clinical studies, a novel and reversible inhibitor (RPI-GLYT2-82), and in the substrate-free state.

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— Azadeh Shahsavar (@azadeh-shahsavar.bsky.social) April 24, 2025 at 10:14 PM

This structure is absolutely _nuts_. Lipids are captured marching through the tunnel

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— Diego del Alamo (@delalamo.xyz) April 26, 2025 at 12:02 PM

Do you want to visualize motion in protein structures? I've used @chimerax.ucsf.edu and little python code to do just that github.com/schaefer-jh/.... Here is some ABC transporter magic. #LLM assisted #coding

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— Jan-Hannes Schaefer (@jhschaef.bsky.social) April 24, 2025 at 10:05 PM

Am having a whale of a time at the @ccpem.bsky.social Spring Symposium today! I have hung out with other crowds too recently, but it's good to be reminded how much fun Structural Biology conferences are. Atomic structure has a beautiful definitiveness to it: it is what it is. 🤗

— Sjors Scheres (@sjorsscheres.bsky.social) April 24, 2025 at 6:27 PM

I'm excited to share our lab's newest publication on the structure and pharmacology of human GABA transporter 3 @natcomms.nature.com. Much to our surprise, GAT3 adopts an inward-open conformation in complex with the (moderately) selective antagonist SNAP-5114. 💊 🧪 #CryoEM #OpenAccess rdcu.be/ei2KY

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— Cornelius Gati (@gati.bsky.social) April 23, 2025 at 11:37 PM

Social media has been great in helping us identify contaminants or cofactors in the past - Any ideas what this complex might be in our HEK293 FLAG pulldown? (We should put together a repository of common contaminants in different cell types)

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— Lander Lab (@landerlab.bsky.social) April 21, 2025 at 7:26 PM

Indeed very cool work, and nothing beats the looks of the Polara to illustrate it!

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— Lars-Anders Carlson (@lacarlson.bsky.social) April 23, 2025 at 10:55 AM

 

X/Twitter cryo-EM & biotech

 

LinkedIN cryo-EM & biotech