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cryoDuck Hottest Social in SBDD (09/2025)

Picture of Mazdak Radjainia

After a bit of a break, we're back with our Hottest Social roundup. On the technical front, cryo-EM researchers pushed past supposed lower limits, resolving sub-40kDa structures with ab initio workflows and calling longstanding size assumptions into question. Meanwhile, China quietly accelerated its biopharma engine, locking in major deals, producing novel drug candidates at record pace, and increasingly outcompeting Western biotech ecosystems. UK biotech, in contrast, weathered a bruising week of exits and retrenchments, raising hard questions about Europe's role in a changing landscape.

Hottest Social SBDD

 

BlueSky cryo-EM & biotech

This one is a bit of a departure from the usual and definitely a work in progress! We found that by using ab initio reconstruction at very high res, in very small steps, we could crack some small structures that had eluded us - e.g. 39kDa iPKAc (EMPIAR-10252), below. Read on for details... 1/x

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— Oli Clarke (@olibclarke.bsky.social) September 13, 2025 at 2:05 AM

Important to remember the theoretical size limit is based on assumptions and a model that may or may not be complete. It isn't some indisputable universal truth.

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— Dimitry Tegunov (@dtegunov.bsky.social) September 13, 2025 at 11:07 PM

We know GLP-1 drugs reduce brain inflammation. But I didn't anticipate bipolar disorder as a possible indication in the future www.nature.com/articles/s41...

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— Eric Topol (@erictopol.bsky.social) September 13, 2025 at 9:20 PM

 

X/Twitter cryo-EM & biotech

 

LinkedIN cryo-EM & biotech