--- title: "Clovertex Target of the Month (08/24): IDH1" description: IDH1 is the August 2024 Clovertex target of the month following FDA approval of Voranigo. image: https://cryoduck.com/hubfs/IDH1.png --- [Skip to content](https://cryoduck.com/blog/idh1#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Oct 1, 2024 10:29:35 PM # Clovertex Target of the Month (08/24): IDH1 ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/idh1) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/idh1) [envelope icon](mailto:?body=https://cryoduck.com/blog/idh1) We are excited to announce that Isocitrate Dehydrogenase 1(IDH1) has been selected as Clovertex’s Target of the Month for August. IDH1 mutations are a key driver in various cancers, particularly gliomas, and are the focus of groundbreaking new treatments such as VORANIGO® (vorasidenib), recently approved by the FDA. This spotlight on IDH1 follows the significant news that Servier Pharmaceuticals has received FDA approval for VORANIGO, marking a major milestone as the first targeted therapy for Grade 2 IDH-mutant glioma. Gliomas are a challenging type of brain cancer, often diagnosed in younger adults, and until now, patients had limited treatment options post-surgery. VORANIGO, an inhibitor of both IDH1 and IDH2, offers glioma patients a chance to actively manage their disease with a convenient, once-daily pill. ![IDH1](https://cryoduck.com/hs-fs/hubfs/IDH1.png?width=1200&height=627&name=IDH1.png) The [Protein Imager](https://academic.oup.com/bioinformatics/article/36/9/2909/5701652?guestAccessKey=69bb093e-3b30-4468-ada7-3ea6ff198636&login=false) rendering displays the cryo-EM structure of isocitrate dehydrogenase (PDB entry [5K10](https://www.rcsb.org/structure/5K10)).   ## About Clovertex Clovertex is an industry leader specializing in meeting the scientific IT needs of pharmaceutical companies, with a robust focus on cloud-based or on-premises cryo-EM processing. As an Advanced Tier Services Partner with Amazon Web Services (AWS), Clovertex leverages its comprehensive expertise to architect, build, automate, and manage software applications designed to meet specific research needs. Our all-encompassing solutions are meticulously tailored to streamline the complex processes associated with pharmaceutical research, underscoring our commitment to innovation, efficiency, and customer satisfaction. By integrating state-of-the-art technology with deep scientific understanding, Clovertex paves the way in optimizing the intersection of information technology and pharmaceutical development. ## Useful links 1. [FDA approves vorasidenib for Grade 2 astrocytoma or oligodendroglioma with a susceptible IDH1 or IDH2 mutation](https://www.fda.gov/drugs/resources-information-approved-drugs/fda-approves-vorasidenib-grade-2-astrocytoma-or-oligodendroglioma-susceptible-idh1-or-idh2-mutation) 2. Clovertex [website](http://clovertex.com) [Clovertex](https://cryoduck.com/blog/tag/clovertex), [target of the month](https://cryoduck.com/blog/tag/target-of-the-month) ## Related posts [![](https://cryoduck.com/hs-fs/hubfs/Trikafta.png?height=200&name=Trikafta.png)](https://cryoduck.com/blog/trikafta) [cryo-EM in drug discovery](https://cryoduck.com/blog/tag/cryo-em-in-drug-discovery), [gene therapy](https://cryoduck.com/blog/tag/gene-therapy) ## [Trikafta: Visualizing three chemical tales in one](https://cryoduck.com/blog/trikafta) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Jun 9, 2023 10:54:39 PM Historically, cystic fibrosis (CF) has been among the most gruesome genetic diseases, often seen as... 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[Read more](https://cryoduck.com/blog/iot-cryoem) [![](https://cryoduck.com/hs-fs/hubfs/Crossroads.png?height=200&name=Crossroads.png)](https://cryoduck.com/blog/academia-vs-industry) [careers in cryo-EM](https://cryoduck.com/blog/tag/careers-in-cryo-em) ## [Transitioning from academia to a cryo-EM career in industry](https://cryoduck.com/blog/academia-vs-industry) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) May 28, 2023 4:46:21 PM Engaging in conversations with students, postdocs, and cryo-EM facility managers, I'm frequently... 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