Here are your MiTeGen Hottest Tweets in SBDD with exciting software developments such as newly...
MiTeGen Hottest Tweets in SBDD (03/24)
Here are your MiTeGen Hottest Tweets in SBDD including a new cryo-EM study revealing the missing piece in why past strategies to safeguard p53 from HPV's grasp have fallen short:
Take the frustration out of clipping your #cryoem grids - Try the new line of grid clipping tools - These tools make loading of c-clips and clip grids easier and help you avoid frost from environmental moisture - Learn More https://t.co/TT4t61Oepb pic.twitter.com/s7qQTpGCYZ
— MiTeGen (@MiTeGen) March 20, 2024
Tough drug targets
Excited to have my maps and models released this week from our time-resolved #cryoEM manuscript. Associated EMPIAR micrograph data sets coming soon, too! 😁 https://t.co/mDvg4SXdQw
— Makaía Papasergi-Scott (@MPapasergiScott) March 7, 2024
Structure of the p53 degradation complex from HPV16https://t.co/gQvCLbVDRZ
— Daniel Hurdiss (@DanielHurdiss) March 1, 2024
The weird and wonderful
Happy to share the results of a great collaboration with Thomas Pfannschmidt (LU Hannover), led by the amazing @paulafprado and Frederik Ahrens. Together, we determined the structure of the multi-subunit plastid-encoded RNA polymerase from chloroplasts!https://t.co/3sBbq6pevn
— Hauke Hillen (@hauke_hillen) February 29, 2024
🧵 pic.twitter.com/JaAwLZMIe6
Sample preparation
Take the frustration out of clipping your #cryoem grids - Try the new line of grid clipping tools - These tools make loading of c-clips and clip grids easier and help you avoid frost from environmental moisture - Learn More https://t.co/TT4t61Oepb pic.twitter.com/s7qQTpGCYZ
— MiTeGen (@MiTeGen) March 20, 2024
Better imaging
Square condenser apertures for square cameras in low-dose transmission electron microscopyhttps://t.co/vzx2JJsYIA
— TKato (@oxkawaka) March 10, 2024
Processing and IT
Just found some real treasures:
— Grigory Tagiltsev (@GrigoryTag) March 5, 2024
In our department we have the original copies of PhD theses of Joachim Frank (Nobel Prize for cryoEM) and Robert Huber (Nobel Prize for the structure of the photosynthetic reaction center)
- the last one has W Hoppe's stamp (Frank's PhD advisor) 🤩 pic.twitter.com/WH1G1nkZ7o
How fast does it take from cells to a publication quality pdb using #cryoem? I thought I'd share a vignette on some workflows @ChemJ_Tsao and I have been working on.
— Matthew Belousoff (@bluesocks81) March 3, 2024
1/n
Nov 2016 is when it all began: with the introduction of (@nvidia ) GPU-accelerated #cryoEM structure determination in #relion; later also with the same algorithm implemented in #cryoSPARC! 😜https://t.co/UkERZzlanp https://t.co/uWqYWRf7lT
— Sjors Scheres (@SjorsScheres) March 3, 2024
Beautiful! It is great to see ppl still building and proud of their own workstations instead of going cloud (or to local IT services which never understand the codes/jobs the WS will run). Reminds of my early #compchem days! :-)
— Guilherme M. Arantes (@ArantesLab) March 2, 2024
Thoughts and opinions
A little over 3 months until delivery of a @thermosciEMSpec #PFIB to @mpibp. This is the room and things are moving at Deutschland-Tempo 🐌. Any suggestions on how to learn to trust the process very welcome 😳 pic.twitter.com/2MwUQSnh8m
— Sonja Welsch (@sonjawelsch) March 7, 2024
Easy is right. Like one clever guy told me, if y'all using sparc, you ain't asking difficult enough questions. pic.twitter.com/DwfPUOW7Qr
— VlaDSSvetlov (@DsSvetlov) March 2, 2024
Biotech news and drug discovery technologies
68% of Venture backed companies have to raise by end of '24 https://t.co/D2zDCGNSvj
— Bijan Salehizadeh (@bijans) March 10, 2024
If you read about a failed drug trial please get that this is what that news feels like to families dying from these diseases. We are the faces of grief and suffering behind those headlines. pic.twitter.com/frnzhG704b
— Sandra Abrevaya (@sabrevaya) March 8, 2024
"A child born with cystic fibrosis in the '50s could expect to live until age 5. In the '70s, age 10. In the early 2000s, age 35. … Today, those who begin taking Trifakta in early adolescence, a recent study projected, can expect to survive to age 82.5." https://t.co/ZuaAqnDdu6
— David Wallace-Wells (@dwallacewells) March 7, 2024
PBMs replacing big pharma as the punching bag on #drugpricing. Good for patients and good for biotech https://t.co/I2DcSuAyZG ht @matthewherper $XBI
— Daphne Zohar (@daphnezohar) March 5, 2024
Ozemphoria
New mechanistic understanding of agonist-mediated GLP-1R internalisation and novel insights into how G protein-coupled receptor kinases may fine-tune GLP-1R signalling. https://t.co/uFoohV7Bz0 #obesity #diabetes #islets
— Daniel J Drucker (@DanielJDrucker) March 11, 2024
Quality of healthcare/drug coverage by @TheEconomist is better than I've seen elsewhere. They are taking the societal, big picture view on value of innovation.
— Peter Kolchinsky (@PeterKolchinsky) March 10, 2024
To see what I mean, check out this piece on weight loss drugs.https://t.co/Zcp8imJgFP
Can GLP-1 medicines exemplified by semaglutide help manage HIV-associated comorbidities? @NatureNV #obesity https://t.co/DfWNhzYW2d
— Daniel J Drucker (@DanielJDrucker) March 11, 2024
Disruptive innovation starts with basic science. The battle over the trillion-dollar #weightloss bonanza https://t.co/wEtBSeKYOT from @TheEconomist
— Daniel J Drucker (@DanielJDrucker) March 4, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.
