Here are your MiTeGen Hottest Tweets in SBDD including a new cryo-EM study revealing the missing...
MiTeGen Hottest Tweets in SBDD (07/24)
Here are your MiTeGen Hottest Tweets in SBDD with exciting software developments such as newly released EMHub or the latest SerialEM/EPU updates.
Streamline your cryo-EM workflow with GridPrepBlock! This innovative tool securely holds up to 5 grids during plasma activation & other surface treatments. Medical grade aluminum, ergonomic design & easy tweezer access make grid prep a breeze. #cryoEM https://t.co/fT4Ad6vQoq pic.twitter.com/XfOm5Y62nb
— MiTeGen (@MiTeGen) July 1, 2024
Tough drug targets
Happy to share our latest work on cytoplasmic mRNA degradation by the Ski-exosome assembly. We reveal via SPA cryoEM how different conformational states of the Ski complex are connected to exosome recruitment and RNA handover. Thanks to everybody involved @LabConti @MPI_Biochem pic.twitter.com/mTDAlOeb2j
— Achim Keidel (@KeidelAchim) October 25, 2023
Glad to present our latest results published today in @Nature revealing the activation mechanism of the AAA+-dependent IS21 transposase. Congrats to all the authors!@CIB_CSIC, @CSIC
— Ernesto Arias-Palomo (@EAriasPalomo) June 27, 2024
Full story here:https://t.co/NMR2ASqP49https://t.co/SmX8i15Zwa
and brief summary below 👇🧵 pic.twitter.com/2Hm3HTA7KA
Interesting: Cryo-EM structure of neurotensin receptor 1 in complex with beta-arrestin1 and SBI-553 (complex 3)#gpcrhttps://t.co/vS1L0qLUxN
— BryanRoth (@zenbrainest) June 26, 2024
The HIV Co-Receptor CCR5 active structure from our collaboration https://t.co/upSt93TRze
— Gebhard F X Schertler (@GSchertler) June 26, 2024
In its final form out today: The complex structure of human tRNA methyltransferase METTL6 in complex with a fully modified serine tRNA and seryl-tRNA synthetase (SerRS). https://t.co/MsAkh5PUWK. All maps, models and micrographs are out as well! Some highlights: pic.twitter.com/OF6wb0vs33
— Eva Kowalinski (@KowaEva) June 25, 2024
Very excited to share our latest paper! We solved the structure of the helper NLR NRC2 activated by the virus resistance protein Rx using cryo-EM. It forms a hexameric inflammasome-like resistosome!
— Jogi Madhuprakash (@JMadhuprakash) June 20, 2024
1/14https://t.co/Om76TJ93XF pic.twitter.com/P8EJ2wXwNY
The weird and wonderful
Our manuscript
— John Rubinstein (@RubinsteinJohn) June 20, 2024
High-resolution electron cryomicroscopy of V-ATPase in native synaptic vesicles
is now published in Science!https://t.co/NUWTFo84Ch pic.twitter.com/G1S3FyAdV1
2D classes of a few particles from a contaminant on our sample, am I the only one seeing evil ? 🤣 #cryoemcanbefun @unimelb @Bio21Institute pic.twitter.com/jZ1Gzdpxp6
— Eric Hanssen (@big_french_man) June 17, 2024
Sample preparation
Getting ready to start #ACA2024 with Craig Yoshioka by leading WK-3: Hands-on CryoEM Sample Preparation & Data Collection Workshop Using #CryoEM Merit Badges.
— Edward T Eng (@edward_eng) July 7, 2024
We thank our sponsors @NanoSoftCryoEM @altos_labs @thermosciEMSpec @MiTeGen & the CryoEM/Service SIGs for their support. https://t.co/W1ocz7ahpB pic.twitter.com/9PrgCgybDF
Have you visited the MiTeGen booth #313 at the ACA Annual meeting yet? You'll find an array of our #cryoem & #crystallography tools & instruments. This includes the manual plunge cooler & cryostat https://t.co/gsH6pgm7gl - Watershed https://t.co/xxh1iOtPus & much more #aca2024 pic.twitter.com/yq5ksNOVW7
— MiTeGen (@MiTeGen) July 9, 2024
Better imaging
Smart EPU 3.8 is a big release!
— Ieva Drulyte (@IevaDrulyte) June 21, 2024
✅️ plasmon imaging
✅️ full support for tilted acquisition
✅️ ice thickness prediction for the selection of foil holes during screening
Visit Smart EPU YouTube channel to learn about the new features:https://t.co/LX5wdFhztx
Last week's release of #SerialEM beta testing introduces "Multiple Grid Ops", an interface to auto acquire grid maps, square maps, and final data from multiple grids in a row using @thermosciEMSpec /@JEOLUSA autoloaders. pic.twitter.com/6besZUhqug
— Guenter Resch (@Nexperion) June 18, 2024
Dear #cryoem comrades. Check out our preprint on how 100 keV detectors help breathe fresh life into ubiquitously available LaB6-based TEM workhorses. A collaboration with @GatanMicroscopy, @GeorgRamm, and @CryoEM_Monash. https://t.co/NOo13IZtqN
— Hari Venugopal (@HariVenugopal2) May 28, 2024
Processing and IT
Crafted with ❤️ for the scientific community and totally open-source! Don't hesitate to get in contact. https://t.co/q7yvPGXAxb
— JM de la Rosa Trevin (@delarosatrevin) July 16, 2024
For the rest of the world, there is this pic.twitter.com/9fJiHJRsM3
— Dimitry Tegunov (@DTegunov) July 5, 2024
New paper out in bioarxiv!. In collaboration with the team of Maks Ovsjanikov, Vincent Mallet developed an algorithm that is available as a plug-in for @UCSFChimeraX to find antibodies and nanobodies, within seconds, in #cryoem densities. https://t.co/7wR2FIjxdN. Try it out!
— Chiara Rapisarda (@chiara_rapi) May 19, 2024
Thoughts and opinions
Anonymous "likes" enable fake likes. This can simulate engagement that encourages users to create content & stay online (increasing the value of X), and can also adjust behaviour by rewarding specific messages.
— John Rubinstein (@RubinsteinJohn) June 13, 2024
Now even the echos in the echo chamber aren't necessarily real.
Biotech news and drug discovery technologies
Wow--mind blown!
— BryanRoth (@zenbrainest) June 19, 2024
"Computational design of soluble and functional membrane protein analogues"@BShoichet @RothLabUNC https://t.co/o6xRH3LixM pic.twitter.com/5fv0vOifh0
My experience with #alphafold3 after determining the #cryoEM structures of he #CRISPR associated transposon complex,
— Guillermo Montoya (@g1_guillermo) June 15, 2024
we tested #alphafold3 in this complex (1/9)
CheckMolecular Cell 👇
https://t.co/vGEKFU4U7l
and @proteofrankie tweetorialhttps://t.co/iFOKuUYm2W pic.twitter.com/QGN9g507BW
Ozemphoria
Another snapshot of GLP-1 medicine use in the real world highlights the persistence adherence problem in people with chronic cardiometabolic disorders. New solutions are needed to achieve better outcomes #T2D #Obesity https://t.co/6cglfwCrYv
— Daniel J Drucker (@DanielJDrucker) July 10, 2024
Weight loss drugs are the new iPhone pic.twitter.com/bgRM29P6nq
— Dare Obasanjo🐀 (@Carnage4Life) June 29, 2024
Just published @NEJM
— Eric Topol (@EricTopol) June 21, 2024
Tirzepatide (GLP-1) clicks for protection vs sleep apnea in 2 randomized placebo-controlled trials: less symptoms, hypoxia, systolic BP, and reduction of inflammation by hs-CRP (w/ or w/o CPAP)https://t.co/gy0iCjS7X8 @AtulMalhotra13 #ADA2024 pic.twitter.com/3H6QON8RGy
Here the authors put forward the case for tirzepatide and GIP act directly in adipocytes to influence adipose tissue metabolism @Cell_Metabolism https://t.co/W5Wlo3ONN2
— Daniel J Drucker (@DanielJDrucker) June 15, 2024
Eli Lilly CEO Dave Ricks says on @WSJ podcast that the company probably needs "10 or 15" plants to "even approach" tirzepatide demand, each of which takes 3-4 years to get up and running. They're building 6 now: https://t.co/dS9hAdjxN9
— Meg Tirrell (@megtirrell) June 12, 2024
Is there a link between Semaglutide and erectile dysfunction? https://t.co/IXIc0kURI1
— Daniel J Drucker (@DanielJDrucker) May 22, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.
