Here are your MiTeGen Hottest Tweets in SBDD, featuring heated discussions about the Inflation...
MiTeGen Hottest Tweets in SBDD (05/24)
Here are your MiTeGen Hottest Tweets in SBDD: While the AlphaFold 3 release made a big splash with everyone wondering whether our jobs are safe, the CryoSparc 4.5 release added automated selection of 2D and 3D classes, which is vital for automated reconstruction helping to keep cryo-EM relevant.
Tough drug targets
The structure of a real 20 kDa protein using an electron microscope π
β Andreas Boland (@BolandLab_GE) May 16, 2024
Very cool work from the Gonen lab determining the structure of MP20, the second most abundant membrane protein of the human eye lens that was reluctant to structure determination for many years. https://t.co/TMcCvGW8CN
GLP-1 analogues that induce prolonged signaling relative to GLP-1 @PatrickMSexton1 https://t.co/ocDCmL8U9W pic.twitter.com/gVcHaE1Anj
β Daniel J Drucker (@DanielJDrucker) April 21, 2024
Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A | Nat Commun https://t.co/b5TUVZq2HQ pic.twitter.com/yH8G9TGvsw
β Membrane Protein PDB (@MemProtPDB) April 19, 2024
The weird and wonderful
Just how big can proteins get? Wow!
β Smart Biology (@SmartBiology3D) May 6, 2024
Learn more at https://t.co/rZjuFXgP1n#biology #3D #science #animation #protein pic.twitter.com/9jAWFdjq9t
Sample preparation
Dear X-friends, Now that I am a poor scientist in a country where science is not a priority, I have to be careful with my expenses. I saw that NanoSoft sells (cheaper) auto grids and C-clips, anyone has experience with them? As good as TFS or crazy idea to buy them? Thanks!
β Israel Fernandez (@IsraelF96135088) May 13, 2024
Do you have samples that need to be stored & shipped? Then watch our #cryoem storage & transport puck video to learn how to efficiently store & ship your samples on grids for single particle analysis & other Cryogenic Electron Microscopy applications. https://t.co/LQLfLpVSMC pic.twitter.com/3tODRWSbjN
β MiTeGen (@MiTeGen) May 6, 2024
Better imaging
Incredible state-of-the-art cryo-EM. At Astex Pharma in Cambridge. pic.twitter.com/zuaFYnSPKs
β Brad Loncar (@bradloncar) May 3, 2024
Best practical course I've ever attended, big Thank You to all involved! Really hope this is the start of a long tradition. Here's Sven driving the Arctis. https://t.co/Hu8mIC71FI pic.twitter.com/FobRY2sZB5
β Wim Hagen (@WimJHH) April 21, 2024
Processing and IT
New paper out in bioarxiv!. In collaboration with the team of Maks Ovsjanikov, Vincent Mallet developed an algorithm that is available as a plug-in for @UCSFChimeraX to find antibodies and nanobodies, within seconds, in #cryoem densities. https://t.co/7wR2FIjxdN. Try it out!
β Chiara Rapisarda (@chiara_rapi) May 19, 2024
1/ CryoSPARC v4.5 is here! π
β Structura Biotechnology (@structurabio) May 7, 2024
Updates include a new micrograph denoiser, automatic 2D/3D class selection, direct file upload, new orientation diagnostics, improvements to Workflows, 3D classification, motion correction, volume alignment, and more! https://t.co/M3mLGtFhSS pic.twitter.com/yfucSlbNVe
Very happy to finally finish this paper and the corresponding code and tutorial. Grateful to all those who helped make this happen. Hopefully it will contribute to making #cryoET more accessible. #teamtomohttps://t.co/6kLbAKrpci
β Sjors Scheres (@SjorsScheres) April 27, 2024
Thoughts and opinions
New sign in our L120C room #science 0 pic.twitter.com/pgTBPFmPSq
β Matthew Belousoff (@bluesocks81) April 22, 2024
Spent time w/ other biotech CEOs this week and it struck me how much humility this industry teaches its leaders. Even successes are viewed through a lens of learning rather than arrogance. "Every new medicine that makes it to patients is a little miracle"
β Daphne Zohar (@daphnezohar) April 21, 2024
Biotech news and drug discovery technologies
"If we take the success rates we observed for AI-discovered molecules in Phase I and II and assume that these hold in the future, and if we combine these with historic Phase III success rates, a striking picture emerges:
β David Li (@davidycli) May 7, 2024
the probability of a molecule succeeding across allβ¦
Can biotech startups upstage big pharma? Percentage of clinical trials run by small biopharma over 70% of total. $XBIhttps://t.co/bNiqseT8LN pic.twitter.com/gNB95su9xC
β Richard J Law π--πΊπ¦ π (@drrichjlaw) May 4, 2024
Ozemphoria
Payor database study of spinal fusion surgery - researchers posit that sarcopenia and/or bone loss could be causing 12x (!) higher second surgery rate in GLP-1 patients. This needs to be investigated.
β Bijan Salehizadeh (@bijans) May 8, 2024
"people taking semaglutide were nearly 12 times more likely to have anβ¦
For the anti Ozempic crowd:
β Abud Bakri MD π (@AbudBakri) May 4, 2024
A person has been dieting for 10+ years and hasn't been successful. Tried many diets, goes to gym, etc
We all know that person. The "always dieting"
They haven't succeeded
Do you want them to continue to try (and fail) for another 10 years, end up⦠pic.twitter.com/DCRbjFkjWh
SURMOUNT-OSA Tirzepatide and obstructive sleep apnea https://t.co/I9kDQWvwP4
β Daniel J Drucker (@DanielJDrucker) April 17, 2024
AlphaFold My Laundry (phrase stolen from Dr. Caroline Bartman)
Although it is a very exciting development, it is sad to see that no code will be released, which would not be allowed for academic institutions @nature. It was clear that weights will not be released (despite being trained purely on public data) but this I did not expect. https://t.co/kAOC08wSr6
β Martin Pacesa (@MartinPacesa) May 8, 2024
I agree that AI+biology is the future, but hype is getting way too high, incl. with AF3.
β Pratyush Tiwary (@tiwarylab) May 8, 2024
From my little bubble of interest:
* Its performance in docking beats competing *non-SOTA* methods
* It completely does not address conformational diversity except some high level πΏ
* RNAπ₯± https://t.co/fXXHOMhH01
All right, The End guys...
β Israel Fernandez (@IsraelF96135088) May 8, 2024
Or may be not... https://t.co/V96wDnX3ht
Gravity-changing advance from @IsomorphicLabs and @GoogleDeepMind on AI-enabled drug discovery. Entering the "AlphaFold 3" era, now with protein-protein, protein-DNA and small molecule capabilities (also markedly improved primary structure prediction). The rising tide is justβ¦
β Jay Bradner, M.D. (@jaybradner) May 8, 2024
AlphaFold3 launched today, now with prediction capabilities for RNA, DNA, ligands, and PTMs. Results look great. However, it feels more like a marketing strategy-no code shared, using the biosecurity excuse. Hoping for an open-source version soon. Looking at you @MoAlQuraishi :) pic.twitter.com/YSQfRHKSYr
β Martin Steinegger πΊπ¦ (@thesteinegger) May 8, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.