---
title: MiTeGen Hottest Tweets in SBDD (05/24)
description: MiTeGen Hottest Tweets in SBDD, your curated source of recent tweets for those who want to stay up to date with the fast-moving world of Cryo-EM Twitter.
image: https://cryoduck.com/hubfs/Puck%20systems.png
---

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 May 22, 2024 10:40:22 AM

# MiTeGen Hottest Tweets in SBDD (05/24)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia)

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Here are your [MiTeGen](http://www.mitegen.com) Hottest Tweets in SBDD: While the AlphaFold 3 release made a big splash with everyone wondering whether our jobs are safe, the CryoSparc 4.5 release added automated selection of 2D and 3D classes, which is vital for automated reconstruction helping to keep cryo-EM relevant.

![Puck systems](https://cryoduck.com/hs-fs/hubfs/Puck%20systems.png?width=1200&height=627&name=Puck%20systems.png)

## Tough drug targets

> The structure of a real 20 kDa protein using an electron microscope 😉  
> Very cool work from the Gonen lab determining the structure of MP20, the second most abundant membrane protein of the human eye lens that was reluctant to structure determination for many years. [https://t.co/TMcCvGW8CN](https://t.co/TMcCvGW8CN)
> 
> — Andreas Boland (@BolandLab\_GE) [May 16, 2024](https://twitter.com/BolandLab_GE/status/1790972888733893049?ref_src=twsrc%5Etfw)

> GLP-1 analogues that induce prolonged signaling relative to GLP-1 [@PatrickMSexton1](https://twitter.com/PatrickMSexton1?ref_src=twsrc%5Etfw) [https://t.co/ocDCmL8U9W](https://t.co/ocDCmL8U9W) [pic.twitter.com/gVcHaE1Anj](https://t.co/gVcHaE1Anj)
> 
> — Daniel J Drucker (@DanielJDrucker) [April 21, 2024](https://twitter.com/DanielJDrucker/status/1781851194370965994?ref_src=twsrc%5Etfw)

> Structural basis for antiepileptic drugs and botulinum neurotoxin recognition of SV2A | Nat Commun [https://t.co/b5TUVZq2HQ](https://t.co/b5TUVZq2HQ) [pic.twitter.com/yH8G9TGvsw](https://t.co/yH8G9TGvsw)
> 
> — Membrane Protein PDB (@MemProtPDB) [April 19, 2024](https://twitter.com/MemProtPDB/status/1781120056719761833?ref_src=twsrc%5Etfw)

## The weird and wonderful

> Just how big can proteins get? Wow!   
> Learn more at [https://t.co/rZjuFXgP1n](https://t.co/rZjuFXgP1n)[#biology](https://twitter.com/hashtag/biology?src=hash&ref_src=twsrc%5Etfw) [#3D](https://twitter.com/hashtag/3D?src=hash&ref_src=twsrc%5Etfw) [#science](https://twitter.com/hashtag/science?src=hash&ref_src=twsrc%5Etfw) [#animation](https://twitter.com/hashtag/animation?src=hash&ref_src=twsrc%5Etfw) [#protein](https://twitter.com/hashtag/protein?src=hash&ref_src=twsrc%5Etfw) [pic.twitter.com/9jAWFdjq9t](https://t.co/9jAWFdjq9t)
> 
> — Smart Biology (@SmartBiology3D) [May 6, 2024](https://twitter.com/SmartBiology3D/status/1787482453218562366?ref_src=twsrc%5Etfw)

## Sample preparation

> Dear X-friends, Now that I am a poor scientist in a country where science is not a priority, I have to be careful with my expenses. I saw that NanoSoft sells (cheaper) auto grids and C-clips, anyone has experience with them? As good as TFS or crazy idea to buy them? Thanks!
> 
> — Israel Fernandez (@IsraelF96135088) [May 13, 2024](https://twitter.com/IsraelF96135088/status/1790092461487837652?ref_src=twsrc%5Etfw)

> Do you have samples that need to be stored & shipped? Then watch our [#cryoem](https://twitter.com/hashtag/cryoem?src=hash&ref_src=twsrc%5Etfw) storage & transport puck video to learn how to efficiently store & ship your samples on grids for single particle analysis & other Cryogenic Electron Microscopy applications. [https://t.co/LQLfLpVSMC](https://t.co/LQLfLpVSMC) [pic.twitter.com/3tODRWSbjN](https://t.co/3tODRWSbjN)
> 
> — MiTeGen (@MiTeGen) [May 6, 2024](https://twitter.com/MiTeGen/status/1787497556962128055?ref_src=twsrc%5Etfw)

## Better imaging

> Incredible state-of-the-art cryo-EM. At Astex Pharma in Cambridge. [pic.twitter.com/zuaFYnSPKs](https://t.co/zuaFYnSPKs)
> 
> — Brad Loncar (@bradloncar) [May 3, 2024](https://twitter.com/bradloncar/status/1786336769224642568?ref_src=twsrc%5Etfw)

> Best practical course I've ever attended, big Thank You to all involved! Really hope this is the start of a long tradition. Here's Sven driving the Arctis. [https://t.co/Hu8mIC71FI](https://t.co/Hu8mIC71FI) [pic.twitter.com/FobRY2sZB5](https://t.co/FobRY2sZB5)
> 
> — Wim Hagen (@WimJHH) [April 21, 2024](https://twitter.com/WimJHH/status/1782003225937277404?ref_src=twsrc%5Etfw)

## Processing and IT

> New paper out in bioarxiv!. In collaboration with the team of Maks Ovsjanikov, Vincent Mallet developed an algorithm that is available as a plug-in for [@UCSFChimeraX](https://twitter.com/UCSFChimeraX?ref_src=twsrc%5Etfw) to find antibodies and nanobodies, within seconds, in [#cryoem](https://twitter.com/hashtag/cryoem?src=hash&ref_src=twsrc%5Etfw) densities. [https://t.co/7wR2FIjxdN](https://t.co/7wR2FIjxdN). Try it out!
> 
> — Chiara Rapisarda (@chiara\_rapi) [May 19, 2024](https://twitter.com/chiara_rapi/status/1792107456027349255?ref_src=twsrc%5Etfw)

> 1/ CryoSPARC v4.5 is here! 🚀
> 
> Updates include a new micrograph denoiser, automatic 2D/3D class selection, direct file upload, new orientation diagnostics, improvements to Workflows, 3D classification, motion correction, volume alignment, and more! [https://t.co/M3mLGtFhSS](https://t.co/M3mLGtFhSS) [pic.twitter.com/yfucSlbNVe](https://t.co/yfucSlbNVe)
> 
> — Structura Biotechnology (@structurabio) [May 7, 2024](https://twitter.com/structurabio/status/1787869630058442790?ref_src=twsrc%5Etfw)

> Very happy to finally finish this paper and the corresponding code and tutorial. Grateful to all those who helped make this happen. Hopefully it will contribute to making [#cryoET](https://twitter.com/hashtag/cryoET?src=hash&ref_src=twsrc%5Etfw) more accessible. [#teamtomo](https://twitter.com/hashtag/teamtomo?src=hash&ref_src=twsrc%5Etfw)[https://t.co/6kLbAKrpci](https://t.co/6kLbAKrpci)
> 
> — Sjors Scheres (@SjorsScheres) [April 27, 2024](https://twitter.com/SjorsScheres/status/1784193476210327681?ref_src=twsrc%5Etfw)

## Thoughts and opinions

> New sign in our L120C room [#science](https://twitter.com/hashtag/science?src=hash&ref_src=twsrc%5Etfw) 0 [pic.twitter.com/pgTBPFmPSq](https://t.co/pgTBPFmPSq)
> 
> — Matthew Belousoff (@bluesocks81) [April 22, 2024](https://twitter.com/bluesocks81/status/1782200491751211142?ref_src=twsrc%5Etfw)

> Spent time w/ other biotech CEOs this week and it struck me how much humility this industry teaches its leaders. Even successes are viewed through a lens of learning rather than arrogance. "Every new medicine that makes it to patients is a little miracle"
> 
> — Daphne Zohar (@daphnezohar) [April 21, 2024](https://twitter.com/daphnezohar/status/1782021704778199380?ref_src=twsrc%5Etfw)

## Biotech news and drug discovery technologies

> "If we take the success rates we observed for AI-discovered molecules in Phase I and II and assume that these hold in the future, and if we combine these with historic Phase III success rates, a striking picture emerges:
> 
> the probability of a molecule succeeding across all…
> 
> — David Li (@davidycli) [May 7, 2024](https://twitter.com/davidycli/status/1787973056729858294?ref_src=twsrc%5Etfw)

> Can biotech startups upstage big pharma? Percentage of clinical trials run by small biopharma over 70% of total. [$XBI](https://twitter.com/search?q=%24XBI&src=ctag&ref_src=twsrc%5Etfw)[https://t.co/bNiqseT8LN](https://t.co/bNiqseT8LN) [pic.twitter.com/gNB95su9xC](https://t.co/gNB95su9xC)
> 
> — Richard J Law 🚜--🇺🇦 🍉 (@drrichjlaw) [May 4, 2024](https://twitter.com/drrichjlaw/status/1786750399770222640?ref_src=twsrc%5Etfw)

## Ozemphoria

> Payor database study of spinal fusion surgery - researchers posit that sarcopenia and/or bone loss could be causing 12x (!) higher second surgery rate in GLP-1 patients. This needs to be investigated.
> 
> "people taking semaglutide were nearly 12 times more likely to have an…
> 
> — Bijan Salehizadeh (@bijans) [May 8, 2024](https://twitter.com/bijans/status/1788218066410545507?ref_src=twsrc%5Etfw)

> For the anti Ozempic crowd:
> 
> A person has been dieting for 10+ years and hasn't been successful. Tried many diets, goes to gym, etc
> 
> We all know that person. The "always dieting"
> 
> They haven't succeeded
> 
> Do you want them to continue to try (and fail) for another 10 years, end up… [pic.twitter.com/DCRbjFkjWh](https://t.co/DCRbjFkjWh)
> 
> — Abud Bakri MD 📟 (@AbudBakri) [May 4, 2024](https://twitter.com/AbudBakri/status/1786826473900593578?ref_src=twsrc%5Etfw)

> SURMOUNT-OSA Tirzepatide and obstructive sleep apnea [https://t.co/I9kDQWvwP4](https://t.co/I9kDQWvwP4)
> 
> — Daniel J Drucker (@DanielJDrucker) [April 17, 2024](https://twitter.com/DanielJDrucker/status/1780556073713229841?ref_src=twsrc%5Etfw)

AlphaFold My Laundry ([phrase stolen](https://x.com/Caroline_Bartma/status/1483978330978332674) from Dr. Caroline Bartman)

> Although it is a very exciting development, it is sad to see that no code will be released, which would not be allowed for academic institutions [@nature](https://twitter.com/Nature?ref_src=twsrc%5Etfw). It was clear that weights will not be released (despite being trained purely on public data) but this I did not expect. [https://t.co/kAOC08wSr6](https://t.co/kAOC08wSr6)
> 
> — Martin Pacesa (@MartinPacesa) [May 8, 2024](https://twitter.com/MartinPacesa/status/1788228878864876032?ref_src=twsrc%5Etfw)

> I agree that AI+biology is the future, but hype is getting way too high, incl. with AF3.
> 
> From my little bubble of interest:  
> \* Its performance in docking beats competing \*non-SOTA\* methods  
> \* It completely does not address conformational diversity except some high level 🍿  
> \* RNA🥱 [https://t.co/fXXHOMhH01](https://t.co/fXXHOMhH01)
> 
> — Pratyush Tiwary (@tiwarylab) [May 8, 2024](https://twitter.com/tiwarylab/status/1788301120973963602?ref_src=twsrc%5Etfw)

> All right, The End guys...
> 
> Or may be not... [https://t.co/V96wDnX3ht](https://t.co/V96wDnX3ht)
> 
> — Israel Fernandez (@IsraelF96135088) [May 8, 2024](https://twitter.com/IsraelF96135088/status/1788231371472744740?ref_src=twsrc%5Etfw)

> Gravity-changing advance from [@IsomorphicLabs](https://twitter.com/IsomorphicLabs?ref_src=twsrc%5Etfw) and [@GoogleDeepMind](https://twitter.com/GoogleDeepMind?ref_src=twsrc%5Etfw) on AI-enabled drug discovery. Entering the "AlphaFold 3" era, now with protein-protein, protein-DNA and small molecule capabilities (also markedly improved primary structure prediction). The rising tide is just…
> 
> — Jay Bradner, M.D. (@jaybradner) [May 8, 2024](https://twitter.com/jaybradner/status/1788234537169825973?ref_src=twsrc%5Etfw)

> AlphaFold3 launched today, now with prediction capabilities for RNA, DNA, ligands, and PTMs. Results look great. However, it feels more like a marketing strategy-no code shared, using the biosecurity excuse. Hoping for an open-source version soon. Looking at you [@MoAlQuraishi](https://twitter.com/MoAlQuraishi?ref_src=twsrc%5Etfw) :) [pic.twitter.com/YSQfRHKSYr](https://t.co/YSQfRHKSYr)
> 
> — Martin Steinegger 🇺🇦 (@thesteinegger) [May 8, 2024](https://twitter.com/thesteinegger/status/1788230518095671375?ref_src=twsrc%5Etfw)

## About MiTeGen

MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.

With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.

Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:

[Manual Plunge Cooler and Precision Ethane Cryostat:](https://www.mitegen.com/product/manual-plunger-cooler-and-precision-cryostat/)

Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.

[Cryo-EM Starter Kits:](https://www.mitegen.com/product-category/cryo-em/cryo-em-starter-kits/)

Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.

[Cryo-EM AutoGrid Cassette Puck:](https://www.mitegen.com/product/cryoem-autogrid-cassette-puck/)

Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.

These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.

[Contact us at MiTeGen](https://www.mitegen.com/booth/) today to arrange a no obligation consultation to learn how we can help you with your research.

[MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## Related posts

[![](https://cryoduck.com/hs-fs/hubfs/kits.png?height=200&name=kits.png)](https://cryoduck.com/blog/tweets-0424)

[MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [MiTeGen Hottest Tweets in SBDD (04/24)](https://cryoduck.com/blog/tweets-0424)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Apr 19, 2024 10:00:57 PM

Here are your MiTeGen Hottest Tweets in SBDD, featuring heated discussions about the Inflation...

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[![](https://cryoduck.com/hs-fs/hubfs/Hottest%20tweets-2-1.png?height=200&name=Hottest%20tweets-2-1.png)](https://cryoduck.com/blog/tweets-1024)

[MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [MiTeGen Hottest Tweets in SBDD (10/24)](https://cryoduck.com/blog/tweets-1024)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Oct 20, 2024 10:23:07 PM

Here are your MiTeGen Hottest Tweets in SBDD, with tweets coming in in wake of Nobel Prize with...

[Read more](https://cryoduck.com/blog/tweets-1024)

[![](https://cryoduck.com/hs-fs/hubfs/Hottest%20tweets-2-1.png?height=200&name=Hottest%20tweets-2-1.png)](https://cryoduck.com/blog/tweets-1224)

[MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets)

## [MiTeGen Hottest Tweets in SBDD (12/24)](https://cryoduck.com/blog/tweets-1224)

![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) 

 Dec 21, 2024 10:08:32 AM

Here are your MiTeGen Hottest Tweets in SBDD, with mesmerizing protein machinery structures and...

[Read more](https://cryoduck.com/blog/tweets-1224)

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