This month's your MiTeGen Hottest Tweets in SBDD come with highlights across all topics including...
MiTeGen Hottest Tweets in SBDD (10/24)
Here are your MiTeGen Hottest Tweets in SBDD, with tweets coming in in wake of Nobel Prize with much praise for Helen Berman and her contributions towards the PDB that made it possible:
Tough drug targets
"Structural basis for ligand recognition of the human hydroxycarboxylic acid receptor HCAR3"https://t.co/AetRUvLRMW
— Shota Suzuki (@structure_bio36) October 20, 2024
The PROTAC field has come an incredibly long way in just the last few years. Getting structures like this is a huge achievment. https://t.co/KFaw5lrgXZ
— Angelica Parente, PhD (@draparente) October 12, 2024
Excited to see our latest study published in @Nature.
— Andrew Ellisdon (@Dr_Ellisdon) October 5, 2024
We report several structures of the intriguing LYCHOS (GPR155) protein revealing a chimeric structure of a GPCR and a PIN-like transporter domain.https://t.co/qIJ8N4kB4p
The weird and wonderful
The life of each one of us began when a sperm and an egg came together. But what actually happens at a molecular level?
— Victoria Deneke (@deneke_v) October 17, 2024
Our latest work @PauliGroup @CellPress reveals a conserved fertilization complex that bridges sperm and egg in vertebrates! (1/8)https://t.co/FT5oxJb1dx pic.twitter.com/T9HtWW9WGT
Sample preparation
#cryoEM psychology 101: Krios cartridge gripper @MPIbp has anger issues. Or a depressive episode with destructive behaviors. It's done this👇 more than once in the past week. pic.twitter.com/dwL85HYYi7
— Sonja Welsch (@sonjawelsch) October 9, 2024
Better imaging
idk, Autoloader motion looks and sounds normal to me...🤷♀️ https://t.co/vqkDL23uNu pic.twitter.com/TWzNrbLTme
— Sonja Welsch (@sonjawelsch) October 9, 2024
Processing and IT
There is a new tool on BioIcons to turn any protein (in PDB format) into a 2D vector illustration in SVG format. You can upload any PDB file or import from PDB, AlphaFoldDB or ESMFoldDB. Feedback welcome :)https://t.co/grMysO8JV5 pic.twitter.com/4Kms5vJ3fO
— Simon Duerr (@simonduerr) October 1, 2024
Presenting VirtualIce: Generate half-synthetic cryoEM micrographs; helps researchers visualize new proteins & diagnose issues (eg. preferred orientation, aggregation) and provides developers with ground-truths for ML dev (eg. picking, heterogeneity).https://t.co/F0gbuohgfA pic.twitter.com/ICflhb8CRd
— Alex J Noble (@alexjamesnoble) September 30, 2024
Thoughts and opinions
Much of the success of breakthroughs, such as AlphaFold, is thanks to a database of protein structures dreamed up in the 1960s by Helen Berman https://t.co/j7l4MJ5OeU
— nature (@Nature) October 18, 2024
Humanity needs to be able to go deep into chemical space as much as it needs to go into space. Chemputation is the only technology that can make this happen & https://t.co/E1Hx8z0GDD is leading the way! pic.twitter.com/6y8kriebPL
— Prof. Lee Cronin (@leecronin) October 13, 2024
Congratulations to these laurates, but I know we are many who also send our appreciation to @buildmodels, Helen Berman & Stephen Burley today for their long time efforts on PDB - morally this is as much their achievement! https://t.co/NzfPAxEKfU
— Erik Lindahl - eriklindahl.bsky.social (@eriklindahl) October 9, 2024
I'm proud to have contributed 🫡 https://t.co/cvKrteb2CY
— David Dranow, Clone me Again🎗️ (@GntlmnScientist) October 9, 2024
Biotech news and drug discovery technologies
Delighted that I could contribute to the #cryoEM validation of these computationally designed antibodies! https://t.co/iJJkOx0gM5
— Ieva Drulyte (@IevaDrulyte) October 5, 2024
Here's our human protein-protein interactome. We mined the SRA, devised a new distillation dataset for protein complexes, trained a new version of RF2 to screen millions of protein pairs, and identify > 18k binary interactions. https://t.co/rfEOJIlW1x pic.twitter.com/4ApW5LNMDF
— Ian Humphreys (@IanRHum) October 3, 2024
Ozemphoria
GLP-1 BY THE NUMBERS
— Michael "Mike" Albert, MD (@MichaelAlbertMD) October 13, 2024
4️⃣7️⃣% are deterred from starting GLP-1 medications due to cost.
3️⃣6️⃣% stopped taking GLP-1 medications because of cost.https://t.co/AagMSWdeJi
The Gartner Hype Cycle has peaked for GLP1s - @FT noe report Regeneron's George Yancopoulos saying they do "more harm than good" due to muscle-losshttps://t.co/wdRFM7aTxV ($)
— David Grainger (@sciencescanner) October 6, 2024
He i right of course. But whats interesting is the change of tone from media reporting it
Will more widespread use of drugs to improve metabolic disorders improve outcomes for #obesity associated #cancer @NatureRevCancer #weightloss #inflammation https://t.co/PgqzSmczot
— Daniel J Drucker (@DanielJDrucker) October 1, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
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Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
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