This month, your MiTeGen Hottest Tweets in SBDD tweets come in the wake of the Ozempic frenzy. The...
MiTeGen Hottest Tweets in SBDD (11/24)
Here are your MiTeGen Hottest Tweets in SBDD, showcasing how laser flash melting might revolutionize sample prep:
Tough drug targets
🚨Paper alarm
— Andreas Boland (@BolandLab_GE) November 21, 2024
Our new work on APC/C regulation revealed by high resolution cryo-EM structures together with the groups of Leifu Chang and David Barford has been published @NatureComms. Congratulations to Anna Höfler, Jun Yu and all other authors.
🔗https://t.co/cWizTIaTNx pic.twitter.com/JSJjoAXdFA
Structure of a dimeric full-length ABC transporterhttps://t.co/WYPpeFyLnC
— Kato (@oxkawaka) November 16, 2024
Structural mechanisms of potent lysophosphatidic acid receptor 1 activation by nonlipid basic agonists | Commun Biolhttps://t.co/YOurlkKrOl pic.twitter.com/pDljtQ0hP6
— Membrane Protein PDB (@MemProtPDB) November 7, 2024
The weird and wonderful
Calcins are scorpion-derived peptides that can cross the plasma membrane and modulate the Ryanodine Receptor. Marvin presenting the latest cryoEM results from our lab at the 2024 Translational Arrhythmia Day (TADA) meeting.
— Filip Van Petegem (@FilipPetegem) November 23, 2024
(description also here: https://t.co/xjcrLzeRbN) pic.twitter.com/rvstFkHLlX
Sample preparation
Proud of new work https://t.co/VVD4eyFOlc from the lab by Zhicheng (Chen) Cui @Chen3dem using single-particle cryo-EM on liposomes to show how mTORC1 integrates nutrient and growth factor signaling at lysosomes, collab. w/ @G__Napolitano, A. Esposito, and A. Ballabio. pic.twitter.com/7KmuqMhFEQ
— Hurley Lab (@TheHurleyLab) November 16, 2024
I'm happy to share our work on laser flash melting to overcome preferred orientation in cryo-EM samples! 🥳❄️🔬
— Monique Straub (@moniquesstraub) November 22, 2024
More infos on the underlying mechanism of particle redistribution and the use for preferred orientation issues in the 🧵 or here: https://t.co/mpdxzbfNpQ pic.twitter.com/dw5GtECf3L
Better imaging
Our #microED #3DED symposium and short course has started.
— Edward T Eng (@edward_eng) November 4, 2024
CryoEM is more than one modality, find out more: https://t.co/8NESJmyWsp https://t.co/r1gVuIJfni pic.twitter.com/fg33WVl8dJ
Processing and IT
OK, @DustinMorado here we go, same job with/without blush regularization. It looks quite similar, same res and Bfact (-41). pic.twitter.com/tbORzMcVQZ
— Israel Fernandez (@IsraelF96135088) October 21, 2024
Thoughts and opinions
In today's #Biotech market - more than ever before - you need an "unfair advantage" to win.
— Shahram Seyedin-Noor (@ShahramSN) November 19, 2024
Rise of "mega" rounds = growing gap b/w the "haves vs. have nots" in biotech.
There has been a flight towards quality: 65% of total VC dollars have gone into relatively few companies… pic.twitter.com/L8RwcVToLA
What I most valued about Twitter was following journal, news, biopharma, and sports feeds, and the diverse community of scientists I meet and sometimes collaborate with. I love amplifying cool discoveries and celebrating scientists' accomplishments where the world rarely does/1
— Carolyn Bertozzi (@CarolynBertozzi) November 16, 2024
Stay frosty. Another 20-point drop coming when he announces Jenny McCarthy will be leading his FDA.
— Paul Narrenschiff (@TheNarrenschiff) November 14, 2024
the vertex CF story
— Martin Shkreli (@MartinShkreli) November 15, 2024
CART
antibodies
recombinant proteins
gene therapy
mRNA
immunooncology
immunology advances in RA, CD/UC, PSO, etc.
pneumococcal vaccines
hepatitis C cure
HIV as a liveable disease
all of this happened in AMERICA. be proud of your amazing fellow citizens (2/2)
Biotech news and drug discovery technologies
Novartis is paying $150m upfront and over $2b in biobucks to Schrodinger, in a deal over several preclinical drug programs
— Andrew Dunn (@AndrewE_Dunn) November 12, 2024
The deal seems to be overshadowing Q3 software revenue coming in slightly below expectations — $SDGR +8% premarket:https://t.co/G8D4ad52C3
Ozemphoria
This excellent @WSJ 📊 shows just how big of a role Obesity holds in the current BioTech & big Pharma landscape. @novonordisk & @EliLillyandCo have long detached from their peers with $NVO trading at 26 times its projected 2025 earnings & $LLY at 40 times! Amazing! $XBI pic.twitter.com/wkmVm94YZk
— Yair Einhorn (@yaireinhorn) October 29, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.
