Shots fired: When is it time-resolved? What's the resolution? China to break into TEM? JEOL =...
Introducing the Hottest Tweets in SBDD sponsored by MiTeGen, your curated source of recent tweets for those who want to stay up to date with the fast-moving world of Cryo-EM Twitter but may not have the time to actively engage.There are a couple tweets from Sjors Scheres that are particularly noteworthy. The first hinted at potential breakthroughs for overcoming high noise levels that often impact resolution in the study of low molecular weight complexes. The second tweet, intriguingly, suggests an imminent feature in the RELION software that could significantly advance the cryo-EM field. Given these developments, one can't help but wonder if RELION is on the verge of introducing a game-changer for drug targets that are currently too small for cryo-EM. Please find the rest of your Hottest Tweets in SBDD below:
Tough drug targets
Allosteric modulation of M4 mAChR
Dopamine receptors structural genomis
The weird and wonderful
Sample preparation
Better imaging
Processing and IT
Improving maps with deep learning
Thoughts and opinions
Over-interpreting enhanced maps
Biotech news and drug discovery technologies
Computational protein binder design
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.
