In this edition of MiTeGen Hottest Tweets in SBDD, the biotech world is manic about incretin...
MiTeGen Hottest Tweets in SBDD (09/24)
Here are your MiTeGen Hottest Tweets in SBDD, featuring a real gem with the hemoglobin structure of crocodile in our Weird & Wonderful category:
Tough drug targets
Check out NuA4/TIP60 in @ScienceMagazine .
โ The Nogales Lab (@NogalesLab) August 1, 2024
We show how this molecular Swiss army knife integrates histone exchange and acetylation in one complex to maintain genome stability ๐งฌ Congrats to @zhenlinUCB and @mameri_amel who co-first authored this work! ๐งตโฌ๏ธ https://t.co/v1UUNeogW4 pic.twitter.com/zMCLzgPzLa
Cryo-EM structure of the bicarbonate receptor GPR30https://t.co/lc7IPuGhkr
โ Cheers (@raintank2010) August 1, 2024
The weird and wonderful
This is an elegant study showing the differences in structures of hemoglobin in humans and crocodiles which explains why crocs can stay long under water. Very cool ๐๐๐
โ Misha Kudryashev ๐ฌ โ๐๏ธ (@MishaKudryashev) August 7, 2024
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EMhttps://t.co/eKdbtd2cng
Sample preparation
Big news soon for #cryoem macromolecular #MicroED...watch this space ๐ณ pic.twitter.com/WvEzMPOLxa
โ Tamir Gonen ๐๏ธ (@gonenlab) August 27, 2024
MiTeGen Newsletter is Out! Features - Article On Ice Formation And Its Elimination In Cryopreservation Of Oocytes - Cryogenic Protective Apparel - Crystallography Scholarship - Quantifoil Grid R 1.2/1.3 Grids - Upcoming Events, News - And more - Read -> https://t.co/sbCGlaKpOP pic.twitter.com/m20uSyvtAe
โ MiTeGen (@MiTeGen) September 18, 2024
In this study, we introduce MAASTY, a novel class of copolymers designed for isolating membrane proteins in native nanodiscs. Here's a quick rundown of our key findings ๐งต
โ Henriette E Autzen (@HenrietteAutzen) August 20, 2024
Better imaging
The first of a series of new #SerialEM tutorial videos is online - Autocontouring of Grid Squares. Let us know what you think and what topics you would like to see covered in the future! https://t.co/cxuIytWTg4
โ Guenter Resch (@Nexperion) September 19, 2024
Processing and IT
Some thoughts on the current state of single particle cryo-EM map/model validation. (TLDR: preferred orientation remains a big problem, โค๏ธ Q-scores. There's been progress, but there's still more to do. ) https://t.co/E3jcBOyeKA pic.twitter.com/6kZnkWcqWx
โ Lander Lab (@LanderLab) September 18, 2024
Cryo-EM is a bit of an imaging miracle. We collect 2D images with stupid amounts of noise. We don't know what we're looking at, or from which way. Yet some how we can churn it over and get to see (actually see) how life works on molecular scales in 3D. How? pic.twitter.com/W5PYQ39hJC
โ Bjorn Forsberg (@bforsb) September 13, 2024
Ahhh... The future has arrived...
โ Matthew Belousoff (@bluesocks81) July 29, 2024
https://t.co/qweNALxah5
Thoughts and opinions
Science "Why are they leaving?" https://t.co/xRsCmPrTQR
โ ใจใใใ (@biochem_fan) September 15, 2024
This reminds me that a PI has to take care of not only scientific but also human/emotional aspects of the team. This is something I cannot/don't want to do and it was a right choice for me to have declined a promotion offer.
with an $8M pullup bar I should get swole much more quickly, right? pic.twitter.com/NLwAQkA5DV
โ Jason Kaelber (@Kaelberviridae) August 8, 2024
Biotech news and drug discovery technologies
Lilly-backed Superluminal raises $120M series A to bring membrane receptor drugs into the clinic https://t.co/gpXtd7rwiI
โ Cheers (@raintank2010) September 11, 2024
Genentech dissolves cancer immunology department
โ Andre-ACGT (@Andre_AGTC) August 16, 2024
Is it a direct result of the IRA - price control of small molecule drugs?
Why spend 12y and >1b to enjoy only 7y exclusivity
Probably more big pharma will start dropping small molecule programs https://t.co/KO0fXI51w9
Ozemphoria
It's a good point. Remember that until recently, the probability of success in developing effective and safe obesity drugs was zero. Just because we've seen generational success with one class does not mean doing this again will now be easy
โ Ethan J. Weiss (@ethanjweiss) September 20, 2024
The next wave of innovation includes small molecule GLP-1R agonists. Beyond time to Cmax, and peak-trough ratios, lucky and good are both important features of drug development #Obesity #T2D https://t.co/MgCG0CQmsA pic.twitter.com/gcBX6IH8L6
โ Daniel J Drucker (@DanielJDrucker) August 9, 2024
About MiTeGen
MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection.
With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines.
Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions:
Manual Plunge Cooler and Precision Ethane Cryostat:
Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation.
Cryo-EM Starter Kits:
Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions.
Cryo-EM AutoGrid Cassette Puck:
Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations.
These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency.
Contact us at MiTeGen today to arrange a no obligation consultation to learn how we can help you with your research.
