--- title: MiTeGen Hottest Tweets in SBDD (11/23) description: MiTeGen Hottest Tweets in SBDD, your curated source of recent tweets for those who want to stay up to date with the fast-moving world of Cryo-EM Twitter. image: https://cryoduck.com/hubfs/Hottest%20tweets-Nov-26-2023-01-17-30-5274-PM.png --- [Skip to content](https://cryoduck.com/blog/tweets-1123#main-content) [![cryoDuck Logo](https://cryoduck.com/hs-fs/hubfs/Home/horizontal%20light%20bg.png?width=300&height=66&name=horizontal%20light%20bg.png)](https://cryoduck.com) - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) Open main navigation Close main navigation - [Home](https://cryoduck.com/) - [About](https://cryoduck.com/about) - [Blog](https://cryoduck.com/blog) - [Newsletter](https://cryoduck.com/newsletter) - [Contact us](https://cryoduck.com/contact) [Contact us](https://cryoduck.com/contact) Nov 26, 2023 2:17:38 PM # MiTeGen Hottest Tweets in SBDD (11/23) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Share: [linkedin-in icon](http://www.linkedin.com/shareArticle?mini=true&url=https://cryoduck.com/blog/tweets-1123) [Twitter icon](https://twitter.com/intent/tweet?url=https://cryoduck.com/blog/tweets-1123) [envelope icon](mailto:?body=https://cryoduck.com/blog/tweets-1123) This month's your [MiTeGen](http://www.mitegen.com) Hottest Tweets in SBDD come with highlights across all topics including significant buzz around the latest software updates in RELION and CryoSPARC: > Are you attending the [#PSDI2023](https://twitter.com/hashtag/PSDI2023?src=hash&ref_src=twsrc%5Etfw) meeting [https://t.co/9ZEG4tNDSF](https://t.co/9ZEG4tNDSF) in Cambridge? Then stop by our MiTeGen table and see tools & instruments for structural biology research, whether it's [#cryoem](https://twitter.com/hashtag/cryoem?src=hash&ref_src=twsrc%5Etfw) or [#crystallography](https://twitter.com/hashtag/crystallography?src=hash&ref_src=twsrc%5Etfw) - Stop and talk with Rachel and Joyce to learn more [pic.twitter.com/CaYDbxOLXA](https://t.co/CaYDbxOLXA) > > — MiTeGen (@MiTeGen) [November 13, 2023](https://twitter.com/MiTeGen/status/1724043443679469939?ref_src=twsrc%5Etfw) ## Tough drug targets > Nature research paper: Mechanisms of neurotransmitter transport and drug inhibition in human VMAT2 [https://t.co/l6K7oK3QwD](https://t.co/l6K7oK3QwD) > > — nature (@Nature) [November 3, 2023](https://twitter.com/Nature/status/1720540374920249664?ref_src=twsrc%5Etfw) > Structure of human TRPM8 channel | Commun Biol[https://t.co/jERrjD9EKo](https://t.co/jERrjD9EKo) [#CryoEM](https://twitter.com/hashtag/CryoEM?src=hash&ref_src=twsrc%5Etfw) [#TRPchannel](https://twitter.com/hashtag/TRPchannel?src=hash&ref_src=twsrc%5Etfw) [#MembraneProteins](https://twitter.com/hashtag/MembraneProteins?src=hash&ref_src=twsrc%5Etfw) [pic.twitter.com/msGZu3jrPA](https://t.co/msGZu3jrPA) > > — Membrane Protein PDB (@MemProtPDB) [October 19, 2023](https://twitter.com/MemProtPDB/status/1715045235582243208?ref_src=twsrc%5Etfw) > First time polyamine is visualized in the pore of ionotropic glutamate receptor (iGluR). Structures of AMPA receptor complexes with auxiliary subunits y5 and CNIH2. Collaboration with A. Korman and D. Jones (NYU). [@shantigangwar](https://twitter.com/shantigangwar?ref_src=twsrc%5Etfw) [@LauraYen42](https://twitter.com/LauraYen42?ref_src=twsrc%5Etfw) [@MariaKarela3](https://twitter.com/MariaKarela3?ref_src=twsrc%5Etfw)[https://t.co/TT7NaUOBcQ](https://t.co/TT7NaUOBcQ) [pic.twitter.com/9PBq3wRUZT](https://t.co/9PBq3wRUZT) > > — Alexander Sobolevsky (@AlexanderSobol6) [October 18, 2023](https://twitter.com/AlexanderSobol6/status/1714672655595409747?ref_src=twsrc%5Etfw) > Thrilled to present our manuscript out today in [@CellCellPress](https://twitter.com/CellCellPress?ref_src=twsrc%5Etfw). A tour-de-force on anaphylatoxin complement receptors - 9 (!!!) unique GPCR structures: C3aR/C5aR1, biased/partial/full agonist, Go/Gq, mouse/human. [https://t.co/YDxiqKQTQd](https://t.co/YDxiqKQTQd) [pic.twitter.com/tjzsOuM1GD](https://t.co/tjzsOuM1GD) > > — Cornelius Gati (@CorneliusGati) [October 17, 2023](https://twitter.com/CorneliusGati/status/1714290751415476649?ref_src=twsrc%5Etfw) > 1/3 Today I can proudly present the first preprint from my project group [@mpimoph](https://twitter.com/mpimoph?ref_src=twsrc%5Etfw)![https://t.co/dl8gRNFRYE](https://t.co/dl8gRNFRYE) > > We determined the [#CryoEM](https://twitter.com/hashtag/CryoEM?src=hash&ref_src=twsrc%5Etfw) structure of the Slo1 potassium channel in complex with the regulatory subunit γ1 and propose a mechanism of how γ1 can activate Slo1. [pic.twitter.com/tPan6JCOc4](https://t.co/tPan6JCOc4) > > — Tobias Raisch (@TobiasRaisch) [November 4, 2023](https://twitter.com/TobiasRaisch/status/1720756057331421637?ref_src=twsrc%5Etfw) > new release1 > > SpSLC9C1 in lipid nanodiscs > > apo > 8PCZ: dimer > 8PD2,3,5,7: protomer state 1-4 > > w/ cAMP > 8PD8: dimer > 8PD9: protomer state 1 > > w/ cGMP > 8PDU: dimer > 8PDV: protomer > > "Structures of a sperm-specific solute carrier gated by voltage and cAMP" > > Paulino lab. Nature. [pic.twitter.com/gV3TYCbaLq](https://t.co/gV3TYCbaLq) > > — Hideaki E. Kato (@emeKato) [November 9, 2023](https://twitter.com/emeKato/status/1722505430071746798?ref_src=twsrc%5Etfw) > Nice! > H4 Receptor structures[https://t.co/iFaLEplyXb](https://t.co/iFaLEplyXb) > > — BryanRoth (@zenbrainest) [October 20, 2023](https://twitter.com/zenbrainest/status/1715411652680786142?ref_src=twsrc%5Etfw) ## The weird and wonderful > We're continuing to share the fantastic photos from this year's [#LMBImageCompeition](https://twitter.com/hashtag/LMBImageCompeition?src=hash&ref_src=twsrc%5Etfw) every Friday. > Next up is this runners-up entry of a tomogram of catalase nanocrystals. [pic.twitter.com/LqhPhJauy4](https://t.co/LqhPhJauy4) > > — MRC Laboratory of Molecular Biology (@MRC\_LMB) [November 24, 2023](https://twitter.com/MRC_LMB/status/1728050917746888742?ref_src=twsrc%5Etfw) ## Sample preparation > Here is the relative ice thickness comparison between our MBP and membrane protein data sets (from cryoSPARC). [https://t.co/nyIDPpZcFz](https://t.co/nyIDPpZcFz) [pic.twitter.com/zRGBSqGpxX](https://t.co/zRGBSqGpxX) > > — Han Kim (@Kim\_Hanseong) [November 21, 2023](https://twitter.com/Kim_Hanseong/status/1726767026377834942?ref_src=twsrc%5Etfw) > Attention [#cryoem](https://twitter.com/hashtag/cryoem?src=hash&ref_src=twsrc%5Etfw) Practitioners - A new grid storage box is available featuring easy to see high contrast colors - Works with clipped & unclipped girds - Has unique & enlarged grid chambers - Rotatable transparent protective lid - Learn more [https://t.co/Hw6Fqf1Ied](https://t.co/Hw6Fqf1Ied) [pic.twitter.com/c2rgF2AMzO](https://t.co/c2rgF2AMzO) > > — MiTeGen (@MiTeGen) [October 10, 2023](https://twitter.com/MiTeGen/status/1711758497904480267?ref_src=twsrc%5Etfw) > Found this in my colleague's notes for clipping cryo-EM grids. > > DON'T BREATHE > > EVER! > > 😂 [pic.twitter.com/woSGfuT9XL](https://t.co/woSGfuT9XL) > > — Meryl Haas (@MerylHaas) [October 23, 2023](https://twitter.com/MerylHaas/status/1716545104477863958?ref_src=twsrc%5Etfw) > Take the frustration out of clipping your [#cryoem](https://twitter.com/hashtag/cryoem?src=hash&ref_src=twsrc%5Etfw) grids - Try the new line of grid clipping tools - These tools make loading of c-clips and clip grids easier and helps you avoid frost from environmental moisture - Learn More [https://t.co/TT4t61Oepb](https://t.co/TT4t61Oepb) [pic.twitter.com/4tMZZgLURS](https://t.co/4tMZZgLURS) > > — MiTeGen (@MiTeGen) [November 8, 2023](https://twitter.com/MiTeGen/status/1722282841617400205?ref_src=twsrc%5Etfw) ## Better imaging > Starting with EPU 3.6 the image shift data will be indeed in the file names between the beam tilt id 🎉(photo from EPU 3.6 release notes) [https://t.co/HDNKr1AQDW](https://t.co/HDNKr1AQDW) [https://t.co/w9z5AIkJVD](https://t.co/w9z5AIkJVD) [pic.twitter.com/cf5urjACg9](https://t.co/cf5urjACg9) > > — Dustin Reed Morado (@DustinMorado) [November 7, 2023](https://twitter.com/DustinMorado/status/1721816758519013511?ref_src=twsrc%5Etfw) > So [#cryoEM](https://twitter.com/hashtag/cryoEM?src=hash&ref_src=twsrc%5Etfw) community - do you use an objective aperture when collecting your data? Especially in microscopes with an EF. I know that it depends on the sample but do you see any benefits in data processing when inserted? 🔬 ❄️ > > — Dominik Hrebik (@F4ustus) [October 19, 2023](https://twitter.com/F4ustus/status/1714922956780941789?ref_src=twsrc%5Etfw) ## Processing and IT > I was talking about using 3D Zernike polynomials to "normalise" results from flexibility analyses - code is available and I'm happy to chat about the concept further :) here's a cool movie showing a GPCR reconstruction using a sum of Zernike polynomials to order 150. [https://t.co/OakFNueDxk](https://t.co/OakFNueDxk) [pic.twitter.com/gbQom5MmSZ](https://t.co/gbQom5MmSZ) > > — Charles Bayly-Jones (@bj\_charles) [November 25, 2023](https://twitter.com/bj_charles/status/1728311297253765257?ref_src=twsrc%5Etfw) > I'm not sure if outputs from 3DVA or Mulltibody are suitable for atomic model refinement. These maps are generated with very crude approximations and show many artifacts. There are no half map pairs for validation. [https://t.co/XkcpxtPiWb](https://t.co/XkcpxtPiWb) > > — とりさん (@biochem\_fan) [November 9, 2023](https://twitter.com/biochem_fan/status/1722760758705127914?ref_src=twsrc%5Etfw) > 1/ [#CryoSPARC](https://twitter.com/hashtag/CryoSPARC?src=hash&ref_src=twsrc%5Etfw) v4.4 is here! 🚀 > Updates include tools to streamline repeat [#cryoEM](https://twitter.com/hashtag/cryoEM?src=hash&ref_src=twsrc%5Etfw) processing, reference based motion correction, orientation diagnostics, symmetry tools, improved 3DFlex, caching, data cleanup and more![https://t.co/M3mLGtFPIq](https://t.co/M3mLGtFPIq) [pic.twitter.com/tWl9WzfAlA](https://t.co/tWl9WzfAlA) > > — Structura Biotechnology (@structurabio) [November 8, 2023](https://twitter.com/structurabio/status/1722279117620674619?ref_src=twsrc%5Etfw) > Once again [@bradyajohnston](https://twitter.com/bradyajohnston?ref_src=twsrc%5Etfw) brings a gun to a knife fight. Holograms on his poster 😯 ... that's cheating 😅 [#PPG2023](https://twitter.com/hashtag/PPG2023?src=hash&ref_src=twsrc%5Etfw) [pic.twitter.com/HTjh9iiSBP](https://t.co/HTjh9iiSBP) > > — Perth Protein Group (@PerthProteins) [November 4, 2023](https://twitter.com/PerthProteins/status/1720756731771555865?ref_src=twsrc%5Etfw) > Interesting status update from DeepMind on AlphaFold (just that, no model, paper, or code). All atom version in the works (similar to RFAA). Meaningful gains on small molecules but far from 'solved' (think AF1 vs AF2). Same w/nucleic acids and antibodies. [https://t.co/2hEowQ4gxN](https://t.co/2hEowQ4gxN) [pic.twitter.com/nVetmAXfnV](https://t.co/nVetmAXfnV) > > — Mohammed AlQuraishi (@MoAlQuraishi) [October 31, 2023](https://twitter.com/MoAlQuraishi/status/1719342262688317771?ref_src=twsrc%5Etfw) > Super excited to present [#Blush](https://twitter.com/hashtag/Blush?src=hash&ref_src=twsrc%5Etfw) and with it expand the applicability of cryo-EM. We reconstruct one of the smallest complexes ever with cryo-EM. A 40 kDa protein-RNA complex. [https://t.co/uaNn6RjVdX](https://t.co/uaNn6RjVdX) > > But how do we make sure we're not overfitting? > > 🧵1/4 [pic.twitter.com/KYt31GwHSU](https://t.co/KYt31GwHSU) > > — Dari Kimanius (@kimanius) [October 24, 2023](https://twitter.com/kimanius/status/1716897060124045474?ref_src=twsrc%5Etfw) > [#ModelAngelo](https://twitter.com/hashtag/ModelAngelo?src=hash&ref_src=twsrc%5Etfw) is changing that, as the bulk of [#cryoEM](https://twitter.com/hashtag/cryoEM?src=hash&ref_src=twsrc%5Etfw) structures can now be built automatically. 🤩 > > — Sjors Scheres (@SjorsScheres) [October 21, 2023](https://twitter.com/SjorsScheres/status/1715623675695714364?ref_src=twsrc%5Etfw) > And our new [#DynaMight](https://twitter.com/hashtag/DynaMight?src=hash&ref_src=twsrc%5Etfw) paper is out on [@biorxivpreprint](https://twitter.com/biorxivpreprint?ref_src=twsrc%5Etfw)! 🥳This is [#RELION5](https://twitter.com/hashtag/RELION5?src=hash&ref_src=twsrc%5Etfw)'s answer to modelling molecular flexibility by the amazing Johannes Schwab. He also shows that model bias can be nasty when modelling molecular flexibility with many parameters. > [https://t.co/hvjQb05jl7](https://t.co/hvjQb05jl7) > > — Sjors Scheres (@SjorsScheres) [October 19, 2023](https://twitter.com/SjorsScheres/status/1715027439032619181?ref_src=twsrc%5Etfw) > This is a numbers game and I would estimate many more computers running 24/7 unnecessarily relentlessly emitting CO2. If we could know what jobs are worth running and which are not that would have been great (like deciding which flights are worth taking) 🤣 > > — Tamir Gonen (@gonenlab) [October 18, 2023](https://twitter.com/gonenlab/status/1714652123533906248?ref_src=twsrc%5Etfw) ## Thoughts and opinions > Never considered the work we do "right wing" …we do basic science and are testing hypotheses…nothing more or less. [https://t.co/QuHZSrJpL0](https://t.co/QuHZSrJpL0) > > — BryanRoth (@zenbrainest) [November 23, 2023](https://twitter.com/zenbrainest/status/1727744452217999366?ref_src=twsrc%5Etfw) > Still can't get over the irony that the best platform for myeloma therapy is an Ikaros degrader (lenalidomide) paired with a molecule that blocks protein degradation (bortezomib). [https://t.co/xx89DCPT0A](https://t.co/xx89DCPT0A) > > — Jay Bradner, M.D. (@jaybradner) [November 21, 2023](https://twitter.com/jaybradner/status/1727003605117644889?ref_src=twsrc%5Etfw) > What to do with these relics? [pic.twitter.com/WtZ4dBIYKW](https://t.co/WtZ4dBIYKW) > > — Tamir Gonen (@gonenlab) [November 20, 2023](https://twitter.com/gonenlab/status/1726669619350630511?ref_src=twsrc%5Etfw) > Everything was better in the seventies [#CCPEM](https://twitter.com/hashtag/CCPEM?src=hash&ref_src=twsrc%5Etfw) [#3DEM](https://twitter.com/hashtag/3DEM?src=hash&ref_src=twsrc%5Etfw) > > — Wim Hagen (@WimJHH) [November 15, 2023](https://twitter.com/WimJHH/status/1724882603579216101?ref_src=twsrc%5Etfw) > PSA: [#cryoEM](https://twitter.com/hashtag/cryoEM?src=hash&ref_src=twsrc%5Etfw) folks, don't let your fine motor skills atrophy. I haven't handled a grid in almost 10 years and it showed today. Painfully. [pic.twitter.com/E6Zsw40LUq](https://t.co/E6Zsw40LUq) > > — David Dranow 🇮🇱 (@GntlmnScientist) [October 24, 2023](https://twitter.com/GntlmnScientist/status/1716928447132696585?ref_src=twsrc%5Etfw) > I hate it when biotechs raise money only when their backs are to the wall [$ARQT](https://twitter.com/search?q=%24ARQT&src=ctag&ref_src=twsrc%5Etfw) had many months to raise money when stock was in the teens > now that its at an all time low they are going to dilute holders by over 30% > "raise when you can, not when you have to" > > — Dan Rosenblum (@sharkbiotech) [October 19, 2023](https://twitter.com/sharkbiotech/status/1715102060952117438?ref_src=twsrc%5Etfw) > Smaller protein complexes in the 80kDa range are now routinely solved by [#CryoEM](https://twitter.com/hashtag/CryoEM?src=hash&ref_src=twsrc%5Etfw) meaning a large number of [#Kinases](https://twitter.com/hashtag/Kinases?src=hash&ref_src=twsrc%5Etfw) in complex with substrates/modulators/activators (like our recent MAP kinase [https://t.co/BwBZb8i7Hl](https://t.co/BwBZb8i7Hl)) will be solved in the coming years - exciting times! [https://t.co/5sNYU0m5pS](https://t.co/5sNYU0m5pS) > > — Matthew Bowler (@moncourvoisier) [October 18, 2023](https://twitter.com/moncourvoisier/status/1714732767492075995?ref_src=twsrc%5Etfw) ## Biotech news and drug discovery technologies > We have reached an agreement in principle for Sam Altman to return to OpenAI as CEO with a new initial board of Bret Taylor (Chair), Larry Summers, and Adam D'Angelo. > > We are collaborating to figure out the details. Thank you so much for your patience through this. > > — OpenAI (@OpenAI) [November 22, 2023](https://twitter.com/OpenAI/status/1727206187077370115?ref_src=twsrc%5Etfw) > Pharmas are changing strategy in response to the IRA by favoring biologics and prioritizing large indications over fast-to-market small indications. > > Biotechs need to catch up. > > Read my article for [@timmermanreport](https://twitter.com/timmermanreport?ref_src=twsrc%5Etfw) 👇 [https://t.co/eRijMqVrIH](https://t.co/eRijMqVrIH) > > — Alex Harding (@AlexHarding7) [November 21, 2023](https://twitter.com/AlexHarding7/status/1727027175851958287?ref_src=twsrc%5Etfw) > The ADC space is blowing up: > > • >$125B in partnerships and M&A since 2019, including Pfizer's $43B acquisition of [$SGEN](https://twitter.com/search?q=%24SGEN&src=ctag&ref_src=twsrc%5Etfw) and a record $5.5B upfront deal ($MRK / Daiichi) this year > • Hundreds of assets across thousands of trials > • 8 approvals in the last 5 years (13 total) > > I… [pic.twitter.com/uYf96WljvY](https://t.co/uYf96WljvY) > > — Andrew Pannu (@andrewpannu) [November 21, 2023](https://twitter.com/andrewpannu/status/1726983436563587250?ref_src=twsrc%5Etfw) > A monumental work by John Ingraham and team [@generate\_biomed](https://twitter.com/generate_biomed?ref_src=twsrc%5Etfw) on Chroma✨ for protein design. Congrats!!! 🔥🎉🔥🎉 > > So excited to see it out, fully open source and with experimentally validated xtal structures! Perhaps cryo-EM of the giant complexes next?[https://t.co/D1cMEqoT6G](https://t.co/D1cMEqoT6G) [https://t.co/BwxfllNUm1](https://t.co/BwxfllNUm1) [pic.twitter.com/Q9mCiBORA8](https://t.co/Q9mCiBORA8) > > — Ellen Zhong (@ZhongingAlong) [November 15, 2023](https://twitter.com/ZhongingAlong/status/1724886386761994494?ref_src=twsrc%5Etfw) > U.K. approves world's first CRISPR-based medicine, giving greenlight to therapy for sickle cell, thalassemia [https://t.co/9KtfeNmHjV](https://t.co/9KtfeNmHjV) > > U.K. regulators beat FDA and EMA by approving the [$VRTX](https://twitter.com/search?q=%24VRTX&src=ctag&ref_src=twsrc%5Etfw) [$CRSP](https://twitter.com/search?q=%24CRSP&src=ctag&ref_src=twsrc%5Etfw) therapy for sickle cell. via [@DrewQJoseph](https://twitter.com/DrewQJoseph?ref_src=twsrc%5Etfw) > > — Adam Feuerstein ✡️ (@adamfeuerstein) [November 16, 2023](https://twitter.com/adamfeuerstein/status/1725072024362422311?ref_src=twsrc%5Etfw) > How competitive recent Biotech M&A deals were? > > \*\*Prometheus had 15 parties in the Data room > > Source: Cantor [pic.twitter.com/Dfu8b1NNpD](https://t.co/Dfu8b1NNpD) > > — Paras Sharma (@paras\_biotech) [November 4, 2023](https://twitter.com/paras_biotech/status/1720819509571747888?ref_src=twsrc%5Etfw) > Interesting status update from DeepMind on AlphaFold (just that, no model, paper, or code). All atom version in the works (similar to RFAA). Meaningful gains on small molecules but far from 'solved' (think AF1 vs AF2). Same w/nucleic acids and antibodies. [https://t.co/2hEowQ4gxN](https://t.co/2hEowQ4gxN) [pic.twitter.com/nVetmAXfnV](https://t.co/nVetmAXfnV) > > — Mohammed AlQuraishi (@MoAlQuraishi) [October 31, 2023](https://twitter.com/MoAlQuraishi/status/1719342262688317771?ref_src=twsrc%5Etfw) > [#AtlasRetreat2023](https://twitter.com/hashtag/AtlasRetreat2023?src=hash&ref_src=twsrc%5Etfw) ⁦[@LifeSciVC](https://twitter.com/LifeSciVC?ref_src=twsrc%5Etfw)⁩'s Year In Review is sobering. Interesting to see small molecules ("smiracles"?) still dominating deal appetite. [pic.twitter.com/pVDpzaE35k](https://t.co/pVDpzaE35k) > > — Jeb Keiper (@JebKeiper) [November 3, 2023](https://twitter.com/JebKeiper/status/1720433790894461389?ref_src=twsrc%5Etfw) ## Ozemphoria > All of the available preclinical data(and more to come) support [#weightloss](https://twitter.com/hashtag/weightloss?src=hash&ref_src=twsrc%5Etfw) independent benefits of GLP-1RAs on CVD, inflammation, and metabolic liver disease. Weight loss helps, but it is not the only driver of benefit [https://t.co/wBh9z1FfLQ](https://t.co/wBh9z1FfLQ) > > — Daniel J Drucker (@DanielJDrucker) [November 11, 2023](https://twitter.com/DanielJDrucker/status/1723366380571927039?ref_src=twsrc%5Etfw) > 1/ > > Super interesting data on semaglutide in cardiovascular disease. > > 10% weight loss was enough to show a mortality benefit in LESS THAN 1 year! > > The benefit is going to be so much greater as time goes on. Actuaries better redo their models for annuities and pensions [https://t.co/zc5NF6LAqz](https://t.co/zc5NF6LAqz) [pic.twitter.com/CyVNsMU5sm](https://t.co/CyVNsMU5sm) > > — Jing Liang 🇺🇦 (@AppleHelix) [November 11, 2023](https://twitter.com/AppleHelix/status/1723347864871477586?ref_src=twsrc%5Etfw) > Biotech investors... [pic.twitter.com/muKgF6Kw0V](https://t.co/muKgF6Kw0V) > > — Adam Feuerstein ✡️ (@adamfeuerstein) [November 11, 2023](https://twitter.com/adamfeuerstein/status/1723353038553751898?ref_src=twsrc%5Etfw) > Tirzepatide got a 2nd approval with diff brand name (Zepbound) for obesity. List price is $1,056/mo, same as Mounjaro for diabetes. Same set of doses > > If list price & dosage forms aren't diff, is need for 2 brands b/c of managing rebates in diabetes (PBMs) & diff insurance mix? > > — Bruce Booth (@LifeSciVC) [November 8, 2023](https://twitter.com/LifeSciVC/status/1722333405960872412?ref_src=twsrc%5Etfw) > Several lines of evidence in mice suggest that GLP-1RAs may reduce food intake via Trh Arc neurons that inhibit AgRP neurons and decrease feeding in an AgRP neuron-dependent manner [#obesity](https://twitter.com/hashtag/obesity?src=hash&ref_src=twsrc%5Etfw) [#weightloss](https://twitter.com/hashtag/weightloss?src=hash&ref_src=twsrc%5Etfw) [https://t.co/3Rh19OTsDL](https://t.co/3Rh19OTsDL) [pic.twitter.com/e6rvoJO49a](https://t.co/e6rvoJO49a) > > — Daniel J Drucker (@DanielJDrucker) [November 4, 2023](https://twitter.com/DanielJDrucker/status/1720915061202436294?ref_src=twsrc%5Etfw) > Semaglutide use in PPL with alcohol use disorder. A survey [https://t.co/pR4jKUTFW3](https://t.co/pR4jKUTFW3) [pic.twitter.com/ZSFGD9LQ8K](https://t.co/ZSFGD9LQ8K) > > — Daniel J Drucker (@DanielJDrucker) [November 2, 2023](https://twitter.com/DanielJDrucker/status/1720145106030772724?ref_src=twsrc%5Etfw) > "The market has reached a point of near peak hysteria regarding the impact of GLP-1s" > > follow-on of last week's "GLP1s cure X" topic [@adar170](https://twitter.com/adar170?ref_src=twsrc%5Etfw) [@john\_bresnahan](https://twitter.com/john_bresnahan?ref_src=twsrc%5Etfw) [https://t.co/IXEFcCUQve](https://t.co/IXEFcCUQve) [pic.twitter.com/AvR7Iw4jgK](https://t.co/AvR7Iw4jgK) > > — Bertrand Delsuc (@BertrandBio) [October 18, 2023](https://twitter.com/BertrandBio/status/1714686322747584629?ref_src=twsrc%5Etfw) ## About MiTeGen MiTeGen, founded in 2004 by Cornell University Professor Robert Thorne, is a leading provider of innovative technologies for cryo-EM, crystallography, and other techniques used for probing small molecule and biomolecular structure and function. Our mission is to support researchers in achieving the best possible results throughout the entire process, from sample preparation to data collection. With a strong emphasis on collaboration, we actively work with academic, government, and industrial researchers in over 40 countries to develop and deliver new tools and methods. Our products have gained recognition and trust within the scientific community, as they have been cited in over 4,500 published research articles. By leveraging concepts and technologies from physics and related fields, we tackle practical challenges faced by our friends and collaborators in the life sciences and other disciplines. Driven by a passion for cryo cooling, we would like to showcase three of our innovative cryo-EM solutions: [Manual Plunge Cooler and Precision Ethane Cryostat:](https://www.mitegen.com/product/manual-plunger-cooler-and-precision-cryostat/) Our Manual Plunge Cooler and Precision Cryostat are specifically designed to streamline and optimize your cryo-EM sample vitrification workflow. These systems consist of three components that can be obtained individually or as a complete package, ensuring efficient and successful sample preparation. [Cryo-EM Starter Kits:](https://www.mitegen.com/product-category/cryo-em/cryo-em-starter-kits/) Our Cryo-EM starter kits are curated to equip your laboratory with all the necessary tools conveniently packaged together. These kits are ideal for labs aiming to perform basic grid and sample preparation for cryo-EM within their own facility, even on a reduced budget. The kit includes components essential for cryo-EM sample preparation, as well as sample storage and transport solutions. [Cryo-EM AutoGrid Cassette Puck:](https://www.mitegen.com/product/cryoem-autogrid-cassette-puck/) Our latest addition, the Cryo-EM AutoGrid Cassette Storage and Shipping puck, builds upon the success of our 2nd generation Cryo-EM Puck. This innovative solution allows users to screen samples on a instrument and seamlessly ship the same AutoGrid cassette puck to a collection facility. It also serves as a convenient storage option for facilities, enabling them to store their cassettes in the puck canes designed to fit into cassette loading stations. These cryo-EM solutions exemplify our dedication to enhancing cryo cooling capabilities and simplifying workflows in the field of cryo-EM. MiTeGen continues to push the boundaries of innovation, enabling researchers to advance their structural biology studies with greater ease and efficiency. [Contact us at MiTeGen](https://www.mitegen.com/booth/) today to arrange a no obligation consultation to learn how we can help you with your research. [MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets) ## Related posts [![](https://cryoduck.com/hs-fs/hubfs/Hottest%20tweets-2-1.png?height=200&name=Hottest%20tweets-2-1.png)](https://cryoduck.com/blog/tweets-1024) [MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets) ## [MiTeGen Hottest Tweets in SBDD (10/24)](https://cryoduck.com/blog/tweets-1024) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Oct 20, 2024 10:23:07 PM Here are your MiTeGen Hottest Tweets in SBDD, with tweets coming in in wake of Nobel Prize with... [Read more](https://cryoduck.com/blog/tweets-1024) [![](https://cryoduck.com/hs-fs/hubfs/Glow.png?height=200&name=Glow.png)](https://cryoduck.com/blog/tweets-0724) [MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets) ## [MiTeGen Hottest Tweets in SBDD (07/24)](https://cryoduck.com/blog/tweets-0724) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Jul 17, 2024 2:31:15 PM Here are your MiTeGen Hottest Tweets in SBDD with exciting software developments such as newly... [Read more](https://cryoduck.com/blog/tweets-0724) [![](https://cryoduck.com/hs-fs/hubfs/Hottest%20tweets-3.png?height=200&name=Hottest%20tweets-3.png)](https://cryoduck.com/blog/tweets-0923) [MiTeGen](https://cryoduck.com/blog/tag/mitegen), [hottest tweets](https://cryoduck.com/blog/tag/hottest-tweets) ## [MiTeGen Hottest Tweets in SBDD (09/23)](https://cryoduck.com/blog/tweets-0923) ![Picture of Mazdak Radjainia](https://cryoduck.com/hs-fs/hubfs/PhotoSessions.nl-PWW_9643-bewerkt.jpg?width=50&name=PhotoSessions.nl-PWW_9643-bewerkt.jpg) [Mazdak Radjainia](https://cryoduck.com/blog/author/mazdak-radjainia) Sep 20, 2023 11:03:26 PM Here are your MiTeGen Hottest Tweets in SBDD with DARPin scaffolds stealing the show cracking tough... 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